Cargando…

WNK1 kinase balances T cell adhesion versus migration in vivo

Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and play critical roles in the normal physiological function of T lymphocytes. Using an RNA interference screen we have identified the WNK1 kinase as a regulator of both integrin-mediated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Köchl, Robert, Thelen, Flavian, Vanes, Lesley, Brazao, Tiago F., Fountain, Kathryn, Xie, Jian, Huang, Chou-Long, Lyck, Ruth, Stein, Jens V., Tybulewicz, Victor L. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994873/ https://www.ncbi.nlm.nih.gov/pubmed/27400149 http://dx.doi.org/10.1038/ni.3495

Ejemplares similares

Critical role of WNK1 in MYC-dependent early mouse thymocyte development
por: Köchl, Robert, et al.
Publicado: (2020)

B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice
por: Hayward, Darryl A., et al.
Publicado: (2023)

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
por: Mayes-Hopfinger, Lindsey, et al.
Publicado: (2021)

The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis
por: Thelen, Flavian, et al.
Publicado: (2021)

Osmosensing by WNK Kinases
por: Akella, Radha, et al.
Publicado: (2021)

Zebrafish WNK Lysine Deficient Protein Kinase 1 (wnk1) Affects Angiogenesis Associated with VEGF Signaling
por: Lai, Ju-Geng, et al.
Publicado: (2014)

Hydrostatic Pressure Sensing by WNK kinases
por: Humphreys, John M., et al.
Publicado: (2023)

An update regarding the role of WNK kinases in cancer
por: Xiu, Mengxi, et al.
Publicado: (2022)

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis
por: Sie, Zong-Lin, et al.
Publicado: (2020)

Calcium-Sensing Receptor and Regulation of WNK Kinases in the Kidney
por: Ostroverkhova, Daria S., et al.
Publicado: (2020)

Unanticipated domain requirements for Drosophila Wnk kinase in vivo
por: Yarikipati, Prathibha, et al.
Publicado: (2023)

Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
por: Boyd-Shiwarski, Cary R., et al.
Publicado: (2018)

Role of the WNK-activated SPAK kinase in regulating blood pressure
por: Rafiqi, Fatema H, et al.
Publicado: (2010)

Regulation of the p38-MAPK pathway by hyperosmolarity and by WNK kinases
por: Liu, Zetao, et al.
Publicado: (2022)

WNK4 is the major WNK positively regulating NCC in the mouse kidney
por: Takahashi, Daiei, et al.
Publicado: (2014)

Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4
por: Rafael, Chloé, et al.
Publicado: (2018)

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress
por: Zagórska, Anna, et al.
Publicado: (2007)

Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function
por: Schiapparelli, Paula, et al.
Publicado: (2021)

WNK1-OSR1 kinase-mediated phospho-activation of Na(+)-K(+)-2Cl(-) cotransporter facilitates glioma migration
por: Zhu, Wen, et al.
Publicado: (2014)

Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase
por: Liu, Zhenan, et al.
Publicado: (2021)

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK
por: Schweighoffer, Edina, et al.
Publicado: (2017)

WNK2 Kinase Is a Novel Regulator of Essential Neuronal Cation-Chloride Cotransporters
por: Rinehart, Jesse, et al.
Publicado: (2011)

WNK1 kinase is essential for insulin‐stimulated GLUT4 trafficking in skeletal muscle
por: Kim, Ji‐Hee, et al.
Publicado: (2018)

Investigating Phosphorylation-Induced Conformational Changes in WNK1 Kinase by Molecular Dynamics Simulations
por: Jonniya, Nisha Amarnath, et al.
Publicado: (2019)

A Nod and a WNK (Kinase): Understanding Airway Surface Liquid pH
por: Cook, Daniel P., et al.
Publicado: (2022)

WNK pathways in cancer signaling networks
por: Gallolu Kankanamalage, Sachith, et al.
Publicado: (2018)

NCC regulation by WNK signal cascade
por: Uchida, Shinichi, et al.
Publicado: (2023)

Get in Touch With Dendritic Epithelial T Cells!
por: Thelen, Flavian, et al.
Publicado: (2020)

WNK1 is required during male pachynema to sustain fertility
por: Chi, Ru-pin Alicia, et al.
Publicado: (2023)

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation
por: Schumacher, Frances-Rose, et al.
Publicado: (2014)

Glycogen synthase kinase 3ß functions as a positive effector in the WNK signaling pathway
por: Sato, Atsushi, et al.
Publicado: (2018)

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
por: Huang, Huachen, et al.
Publicado: (2019)

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
por: Chen, Zhuoyao, et al.
Publicado: (2022)

WNK signalling pathways in blood pressure regulation
por: Murthy, Meena, et al.
Publicado: (2016)

WNK1 regulates uterine homeostasis and its ability to support pregnancy
por: Chi, Ru-pin Alicia, et al.
Publicado: (2020)

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
por: Thastrup, Jacob O., et al.
Publicado: (2011)

Comparative Analysis of the Expression Profile of Wnk1 and Wnk1/Hsn2 Splice Variants in Developing and Adult Mouse Tissues
por: Shekarabi, Masoud, et al.
Publicado: (2013)

Polarization of Migrating Monocytic Cells Is Independent of PI 3-Kinase Activity
por: Volpe, Silvia, et al.
Publicado: (2010)

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4(+) T cell–dendritic cell interactions
por: Moalli, Federica, et al.
Publicado: (2014)

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters
por: delos Heros, Paola, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_qvqkp9vbh7ebfdds3hauhbm1um