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Irreversibility of T-Cell Specification: Insights from Computational Modelling of a Minimal Network Architecture
BACKGROUND/OBJECTIVES: A cascade of gene activations under the control of Notch signalling is required during T-cell specification, when T-cell precursors gradually lose the potential to undertake other fates and become fully committed to the T-cell lineage. We elucidate how the gene/protein dynamic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995000/ https://www.ncbi.nlm.nih.gov/pubmed/27551921 http://dx.doi.org/10.1371/journal.pone.0161260 |