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Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells

Interleukin-1 (IL-1) plays a crucial role in numerous inflammatory diseases via action on its only known signaling IL-1 receptor type 1 (IL-1R1). To investigate the role of IL-1 signaling in selected cell types, we generated a new mouse strain in which exon 5 of the Il1r1 gene is flanked by loxP sit...

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Detalles Bibliográficos
Autores principales:	Mufazalov, Ilgiz A., Regen, Tommy, Schelmbauer, Carsten, Kuschmann, Janina, Muratova, Alisa M., Nikolaev, Alexei, Müller, Werner, Pinteaux, Emmanuel, Waisman, Ari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995027/ https://www.ncbi.nlm.nih.gov/pubmed/27551932 http://dx.doi.org/10.1371/journal.pone.0161505

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