High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival

Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood. Using newly generated recombinant antigen va...

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Detalles Bibliográficos
Autores principales: Utzschneider, Daniel T., Alfei, Francesca, Roelli, Patrick, Barras, David, Chennupati, Vijaykumar, Darbre, Stephanie, Delorenzi, Mauro, Pinschewer, Daniel D., Zehn, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995073/
https://www.ncbi.nlm.nih.gov/pubmed/27455951
http://dx.doi.org/10.1084/jem.20150598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995073/
https://www.ncbi.nlm.nih.gov/pubmed/27455951
http://dx.doi.org/10.1084/jem.20150598

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