DNA polymerase ι functions in the generation of tandem mutations during somatic hypermutation of antibody genes

DNA polymerase ι (Pol ι) is an attractive candidate for somatic hypermutation in antibody genes because of its low fidelity. To identify a role for Pol ι, we analyzed mutations in two strains of mice with deficiencies in the enzyme: 129 mice with negligible expression of truncated Pol ι, and knock-i...

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Detalles Bibliográficos
Autores principales: Maul, Robert W., MacCarthy, Thomas, Frank, Ekaterina G., Donigan, Katherine A., McLenigan, Mary P., Yang, William, Saribasak, Huseyin, Huston, Donald E., Lange, Sabine S., Woodgate, Roger, Gearhart, Patricia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995076/
https://www.ncbi.nlm.nih.gov/pubmed/27455952
http://dx.doi.org/10.1084/jem.20151227

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