Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study protocols rely on the ex vivo expansion of donor T reg cells and their infusion in high numbers. In this s...

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Detalles Bibliográficos
Autores principales: Chopra, Martin, Biehl, Marlene, Steinfatt, Tim, Brandl, Andreas, Kums, Juliane, Amich, Jorge, Vaeth, Martin, Kuen, Janina, Holtappels, Rafaela, Podlech, Jürgen, Mottok, Anja, Kraus, Sabrina, Jordán-Garrote, Ana-Laura, Bäuerlein, Carina A., Brede, Christian, Ribechini, Eliana, Fick, Andrea, Seher, Axel, Polz, Johannes, Ottmüller, Katja J., Baker, Jeanette, Nishikii, Hidekazu, Ritz, Miriam, Mattenheimer, Katharina, Schwinn, Stefanie, Winter, Thorsten, Schäfer, Viktoria, Krappmann, Sven, Einsele, Hermann, Müller, Thomas D., Reddehase, Matthias J., Lutz, Manfred B., Männel, Daniela N., Berberich-Siebelt, Friederike, Wajant, Harald, Beilhack, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995078/
https://www.ncbi.nlm.nih.gov/pubmed/27526711
http://dx.doi.org/10.1084/jem.20151563

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