GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

When SUCNR1/GPR91-expressing macrophages are activated by inflammatory signals, they change their metabolism and accumulate succinate. In this study, we show that during this activation, macrophages release succinate into the extracellular milieu. They simultaneously up-regulate GPR91, which functio...

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Detalles Bibliográficos
Autores principales: Littlewood-Evans, Amanda, Sarret, Sophie, Apfel, Verena, Loesle, Perrine, Dawson, Janet, Zhang, Juan, Muller, Alban, Tigani, Bruno, Kneuer, Rainer, Patel, Saijel, Valeaux, Stephanie, Gommermann, Nina, Rubic-Schneider, Tina, Junt, Tobias, Carballido, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995082/
https://www.ncbi.nlm.nih.gov/pubmed/27481132
http://dx.doi.org/10.1084/jem.20160061

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