Cargando…

Probing the functional impact of sub-retinal prosthesis

Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systema...

Descripción completa

Detalles Bibliográficos
Autores principales: Roux, Sébastien, Matonti, Frédéric, Dupont, Florent, Hoffart, Louis, Takerkart, Sylvain, Picaud, Serge, Pham, Pascale, Chavane, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995098/
https://www.ncbi.nlm.nih.gov/pubmed/27549126
http://dx.doi.org/10.7554/eLife.12687
_version_ 1782449419744968704
author Roux, Sébastien
Matonti, Frédéric
Dupont, Florent
Hoffart, Louis
Takerkart, Sylvain
Picaud, Serge
Pham, Pascale
Chavane, Frédéric
author_facet Roux, Sébastien
Matonti, Frédéric
Dupont, Florent
Hoffart, Louis
Takerkart, Sylvain
Picaud, Serge
Pham, Pascale
Chavane, Frédéric
author_sort Roux, Sébastien
collection PubMed
description Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systematic comparison between visual and prosthetic activations of the rat primary visual cortex (V1). We established a precise V1 mapping as a functional benchmark to demonstrate that sub-retinal implants activate V1 at the appropriate position, scalable to a wide range of visual luminance, but with an aspect-ratio and an extent much larger than expected. Such distorted activation profile can be accounted for by the existence of two sources of diffusion, passive diffusion and activation of ganglion cells’ axons en passant. Reverse-engineered electrical pulses based on impedance spectroscopy is the only solution we tested that decreases the extent and aspect-ratio, providing a promising solution for clinical applications. DOI: http://dx.doi.org/10.7554/eLife.12687.001
format Online
Article
Text
id pubmed-4995098
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher eLife Sciences Publications, Ltd
record_format MEDLINE/PubMed
spelling pubmed-49950982016-08-24 Probing the functional impact of sub-retinal prosthesis Roux, Sébastien Matonti, Frédéric Dupont, Florent Hoffart, Louis Takerkart, Sylvain Picaud, Serge Pham, Pascale Chavane, Frédéric eLife Human Biology and Medicine Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systematic comparison between visual and prosthetic activations of the rat primary visual cortex (V1). We established a precise V1 mapping as a functional benchmark to demonstrate that sub-retinal implants activate V1 at the appropriate position, scalable to a wide range of visual luminance, but with an aspect-ratio and an extent much larger than expected. Such distorted activation profile can be accounted for by the existence of two sources of diffusion, passive diffusion and activation of ganglion cells’ axons en passant. Reverse-engineered electrical pulses based on impedance spectroscopy is the only solution we tested that decreases the extent and aspect-ratio, providing a promising solution for clinical applications. DOI: http://dx.doi.org/10.7554/eLife.12687.001 eLife Sciences Publications, Ltd 2016-08-23 /pmc/articles/PMC4995098/ /pubmed/27549126 http://dx.doi.org/10.7554/eLife.12687 Text en © 2016, Roux et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Roux, Sébastien
Matonti, Frédéric
Dupont, Florent
Hoffart, Louis
Takerkart, Sylvain
Picaud, Serge
Pham, Pascale
Chavane, Frédéric
Probing the functional impact of sub-retinal prosthesis
title Probing the functional impact of sub-retinal prosthesis
title_full Probing the functional impact of sub-retinal prosthesis
title_fullStr Probing the functional impact of sub-retinal prosthesis
title_full_unstemmed Probing the functional impact of sub-retinal prosthesis
title_short Probing the functional impact of sub-retinal prosthesis
title_sort probing the functional impact of sub-retinal prosthesis
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995098/
https://www.ncbi.nlm.nih.gov/pubmed/27549126
http://dx.doi.org/10.7554/eLife.12687
work_keys_str_mv AT rouxsebastien probingthefunctionalimpactofsubretinalprosthesis
AT matontifrederic probingthefunctionalimpactofsubretinalprosthesis
AT dupontflorent probingthefunctionalimpactofsubretinalprosthesis
AT hoffartlouis probingthefunctionalimpactofsubretinalprosthesis
AT takerkartsylvain probingthefunctionalimpactofsubretinalprosthesis
AT picaudserge probingthefunctionalimpactofsubretinalprosthesis
AT phampascale probingthefunctionalimpactofsubretinalprosthesis
AT chavanefrederic probingthefunctionalimpactofsubretinalprosthesis