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Development and Validation of a UHPLC UV Method for the In-Process Control of Bosentan Monohydrate Synthesis

Bosentan monohydrate (4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl) pyrimidin-4-yl]benzene-1-sulfonamide monohydrate) is a dual endothelin receptor antagonist (ERA) applied in the treatment of pulmonary arterial hypertension. To achieve effective process control of the...

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Detalles Bibliográficos
Autores principales:	Jatczak, Marta, Sidoryk, Katarzyna, Kossykowska, Magdalena, Łuniewski, Wojciech, Zagrodzka, Joanna, Lipiec-Abramska, Elżbieta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2016
Materias:	Original
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995228/ https://www.ncbi.nlm.nih.gov/pubmed/27616782 http://dx.doi.org/10.1007/s10337-016-3124-y

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