Cargando…

The relationship between RRM1 gene polymorphisms and effectiveness of gemcitabine-based first-line chemotherapy in advanced NSCLC patient

PURPOSE: Chemotherapy with platinum compounds and gemcitabine is frequently used in first-line treatment of advanced non-small cell lung cancer (NSCLC) patients in which tyrosine kinase inhibitors (EGFR or ALK) cannot be administered. Unfortunately, less than half of the patients achieve the benefit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mlak, R., Krawczyk, P., Ciesielka, M., Kozioł, P., Homa, I., Powrózek, T., Prendecka, M., Milanowski, J., Małecka-Massalska, T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995236/ https://www.ncbi.nlm.nih.gov/pubmed/26650486 http://dx.doi.org/10.1007/s12094-015-1461-1

Ejemplares similares

Predictive Value of Single Nucleotide Polymorphisms of ERCC1, XPA, XPC, XPD and XPG Genes, Involved in NER Mechanism in Patients with Advanced NSCLC Treated with Cisplatin and Gemcitabine
por: Mlak, Radosław, et al.
Publicado: (2018)

Predictive value of STMN1 gene promoter polymorphism (−2166T>C) in patients with advanced NSCLC treated with the combination of platinum compounds and vinorelbine
por: Mlak, Radosław, et al.
Publicado: (2015)

Polymorphism of Promoter Region of TNFRSF1A Gene (−610 T > G) as a Novel Predictive Factor for Radiotherapy Induced Oral Mucositis in HNC Patients
por: Brzozowska, Anna, et al.
Publicado: (2017)

AA genotype of PLIN1 13041A>G as an unfavourable predictive factor of malnutrition associated with fat mass loss in locally advanced head and neck cancer male patients treated with radiotherapy
por: Powrózek, Tomasz, et al.
Publicado: (2020)

Impact of I/D polymorphism of ACE gene on risk of development and course of chronic obstructive pulmonary disease
por: Mlak, Radosław, et al.
Publicado: (2016)

Polymorphisms in the Gene Encoding Caspase 8 May Predict the Response to First-Line Platinum-Based Chemotherapy in Locally Advanced or Advanced Non-Small-Cell Lung Cancer
por: Szczyrek, Michał, et al.
Publicado: (2021)

Polymorphism of regulatory region of APEH gene (c.-521G>C, rs4855883) as a relevant predictive factor for radiotherapy induced oral mucositis and overall survival in head neck cancer patients
por: Brzozowska, Anna, et al.
Publicado: (2018)

Association between myostatin serum concentration and body fat level in peri- and postmenopausal women
por: Bojar, Iwona, et al.
Publicado: (2021)

Polymorphism of The Regulatory Region of the ITGAM Gene (-323G>A) as a Novel Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation Therapy
por: Mazurek, Marcin, et al.
Publicado: (2020)

The relationship between TNF-α gene promoter polymorphism (− 1211 T > C), the plasma concentration of TNF-α, and risk of oral mucositis and shortening of overall survival in patients subjected to intensity-modulated radiation therapy due to head and neck cancer
por: Mlak, Radosław, et al.
Publicado: (2019)

TNFRSF1A Gene Polymorphism (−610 T > G, rs4149570) as a Predictor of Malnutrition and a Prognostic Factor in Patients Subjected to Intensity-Modulated Radiation Therapy Due to Head and Neck Cancer
por: Homa-Mlak, Iwona, et al.
Publicado: (2022)

High Level of Irisin as a Marker of Malnutrition in Head and Neck Cancer Patients Subjected to Radiotherapy
por: Homa-Mlak, Iwona, et al.
Publicado: (2022)

Relationship between TNF-α −1031T/C gene polymorphism, plasma level of TNF-α, and risk of cachexia in head and neck cancer patients
por: Powrózek, Tomasz, et al.
Publicado: (2018)

High miR-511-3p Expression as a Potential Predictor of a Poor Nutritional Status in Head and Neck Cancer Patients Subjected to Intensity-Modulated Radiation Therapy
por: Mazurek, Marcin, et al.
Publicado: (2022)

Letter to the editor concerning first-line therapy with afatinib – an irreversible EGFR TKI and overall survival of NSCLC patients with EGFR gene mutations
por: Krawczyk, Paweł, et al.
Publicado: (2015)

Polymorphism of the ITGAM gene (rs7193943) and bioelectric impedance analysis as potential predictors of cachexia in chronic heart failure
por: Sobieszek, Grzegorz, et al.
Publicado: (2021)

Polymorphisms of Genes Encoding Multidrug Resistance Proteins as a Predictive Factor for Second-Line Docetaxel Therapy in Advanced Non-small Cell Lung Cancer
por: Szczyrek, Michał, et al.
Publicado: (2016)

RRM1 single nucleotide polymorphism -37C→A correlates with progression-free survival in NSCLC patients after gemcitabine-based chemotherapy
por: Dong, Song, et al.
Publicado: (2010)

miRNA-130a Significantly Improves Accuracy of SGA Nutritional Assessment Tool in Prediction of Malnutrition and Cachexia in Radiotherapy-Treated Head and Neck Cancer Patients
por: Powrózek, Tomasz, et al.
Publicado: (2018)

Polymorphisms in TS, MTHFR and ERCC1 genes as predictive markers in first-line platinum and pemetrexed therapy in NSCLC patients
por: Krawczyk, Paweł, et al.
Publicado: (2014)

Neutrophil-to-Lymphocyte Ratio as a Factor Predicting Radiotherapy Induced Oral Mucositis in Head Neck Cancer Patients Treated with Radiotherapy
por: Homa-Mlak, Iwona, et al.
Publicado: (2021)

Three Pathways of Cancer Cachexia: Inflammation, Changes in Adipose Tissue and Loss of Muscle Mass—The Role of miRNAs
por: Homa-Mlak, Iwona, et al.
Publicado: (2022)

The Application of Real-Time PCR Technique to Detect Rare Cell Clones with Primary T790M Substitution of EGFR Gene in Metastases of Non-small Cell Lung Cancer to Central Nervous System in Chemotherapy Naive Patients
por: Powrózek, Tomasz, et al.
Publicado: (2014)

Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer
por: Krawczyk, Paweł, et al.
Publicado: (2012)

Anthropometrical and Bioelectrical Impedance Analysis Parameters in Anorexia Nervosa Patients’ Nutritional Status Assessment
por: Popiołek, Joanna, et al.
Publicado: (2019)

Clinical Significance of TNFRSF1A36T/C Polymorphism in Cachectic Patients with Chronic Heart Failure
por: Sobieszek, Grzegorz, et al.
Publicado: (2021)

Electrical Changes in Polish Patients with Chronic Heart Failure: Preliminary Observations
por: Sobieszek, Grzegorz, et al.
Publicado: (2019)

The impact of ACE gene polymorphism on the incidence and phenotype of sarcoidosis in rural and urban settings
por: Kieszko, Robert, et al.
Publicado: (2015)

The Effectiveness of Pemetrexed Monotherapy Depending on Polymorphisms in TS and MTHFR Genes as Well as Clinical Factors in Advanced NSCLC Patients
por: Kucharczyk, Tomasz, et al.
Publicado: (2015)

Nutritional Deficiencies in Radiotherapy-Treated Head and Neck Cancer Patients
por: Powrózek, Tomasz, et al.
Publicado: (2021)

Etiopathogenesis and Diagnostic Strategies in Autoimmune Hepatitis
por: Domerecka, Weronika, et al.
Publicado: (2021)

Polymorphisms in the promoter region of the CRBN gene as a predictive factor for the first-line CTD therapy in multiple myeloma patients
por: Szudy-Szczyrek, Aneta, et al.
Publicado: (2018)

The TT Genotype of the KIAA1524 rs2278911 Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma
por: Szudy-Szczyrek, Aneta, et al.
Publicado: (2023)

Expression of RRM1 and its association with resistancy to gemcitabine-based chemotherapy in advanced nasopharyngeal carcinoma
por: Zhao, Li-Ping, et al.
Publicado: (2012)

The Usefulness of Extended Inflammation Parameters and Systemic Inflammatory Response Markers in the Diagnostics of Autoimmune Hepatitis
por: Domerecka, Weronika, et al.
Publicado: (2022)

The Clinical Relevance of Selected Cytokines in Newly Diagnosed Multiple Myeloma Patients
por: Mielnik, Michał, et al.
Publicado: (2023)

Indicator of Inflammation and NETosis—Low-Density Granulocytes as a Biomarker of Autoimmune Hepatitis
por: Domerecka, Weronika, et al.
Publicado: (2022)

Relationship between microRNA-146a expression and plasma renalase levels in hemodialyzed patients
por: Dziedzic, Marcin, et al.
Publicado: (2017)

Circulating Serum MiRNA-8074 as a Novel Prognostic Biomarker for Multiple Myeloma
por: Szudy-Szczyrek, Aneta, et al.
Publicado: (2022)

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine
por: Jørgensen, Charlotte LT, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_g5ovnmokgjn63crru8dplrlljh