Cargando…

Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer

The application of neoadjuvant androgen deprivation (NAD) in prostate cancer leads to a reduction in prostate volume, and the trends in volume reduction differ according to the treatment duration of NAD. A reduction in volume during external beam radiation therapy may lead to the exposure of normal...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomida, Masashi, Okudaira, Kuniyasu, Kamomae, Takeshi, Oguchi, Hiroshi, Miyake, Yoshikazu, Yoneda, Kazuo, Itoh, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995277/
https://www.ncbi.nlm.nih.gov/pubmed/27578915
_version_ 1782449446785646592
author Tomida, Masashi
Okudaira, Kuniyasu
Kamomae, Takeshi
Oguchi, Hiroshi
Miyake, Yoshikazu
Yoneda, Kazuo
Itoh, Yoshiyuki
author_facet Tomida, Masashi
Okudaira, Kuniyasu
Kamomae, Takeshi
Oguchi, Hiroshi
Miyake, Yoshikazu
Yoneda, Kazuo
Itoh, Yoshiyuki
author_sort Tomida, Masashi
collection PubMed
description The application of neoadjuvant androgen deprivation (NAD) in prostate cancer leads to a reduction in prostate volume, and the trends in volume reduction differ according to the treatment duration of NAD. A reduction in volume during external beam radiation therapy may lead to the exposure of normal tissues to an unexpected dose. In fact, prostate volume reductions have primarily been reported in European and American institutions. Although the prostate volume of Japanese patients is known to be small, the trends in prostate volume change during radiation therapy remain unclear. In the present study, we aimed to evaluate the changes in prostate volume of Japanese patients during intensity-modulated radiation therapy (IMRT) with NAD. Nineteen Japanese patients with prostate cancer underwent IMRT with NAD. Kilovoltage computed tomography (CT) images were obtained for treatment planning and verification of the treatment position for each treatment fraction. The patients were divided into 3 groups based on the duration of NAD, as follows: NAD < 3 months (short NAD: S-NAD), 3 months ≤ NAD < 6 months (middle NAD: M-NAD), and NAD ≥ 6 months (long NAD: L-NAD). The prostate volume reductions at the 36th treatment fraction, relative to the planning CT, were 7.8%, 2.0%, and 1.7% for the S-NAD, M-NAD, and L-NAD groups, respectively. Prostate volume shrunk greater in the S-NAD group than in the M-NAD and L-NAD groups; this finding was consistent with those of previous studies. The prostate volume changes in Japanese patients were smaller compared to those in European and American patients.
format Online
Article
Text
id pubmed-4995277
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nagoya University
record_format MEDLINE/PubMed
spelling pubmed-49952772016-08-30 Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer Tomida, Masashi Okudaira, Kuniyasu Kamomae, Takeshi Oguchi, Hiroshi Miyake, Yoshikazu Yoneda, Kazuo Itoh, Yoshiyuki Nagoya J Med Sci Original Paper The application of neoadjuvant androgen deprivation (NAD) in prostate cancer leads to a reduction in prostate volume, and the trends in volume reduction differ according to the treatment duration of NAD. A reduction in volume during external beam radiation therapy may lead to the exposure of normal tissues to an unexpected dose. In fact, prostate volume reductions have primarily been reported in European and American institutions. Although the prostate volume of Japanese patients is known to be small, the trends in prostate volume change during radiation therapy remain unclear. In the present study, we aimed to evaluate the changes in prostate volume of Japanese patients during intensity-modulated radiation therapy (IMRT) with NAD. Nineteen Japanese patients with prostate cancer underwent IMRT with NAD. Kilovoltage computed tomography (CT) images were obtained for treatment planning and verification of the treatment position for each treatment fraction. The patients were divided into 3 groups based on the duration of NAD, as follows: NAD < 3 months (short NAD: S-NAD), 3 months ≤ NAD < 6 months (middle NAD: M-NAD), and NAD ≥ 6 months (long NAD: L-NAD). The prostate volume reductions at the 36th treatment fraction, relative to the planning CT, were 7.8%, 2.0%, and 1.7% for the S-NAD, M-NAD, and L-NAD groups, respectively. Prostate volume shrunk greater in the S-NAD group than in the M-NAD and L-NAD groups; this finding was consistent with those of previous studies. The prostate volume changes in Japanese patients were smaller compared to those in European and American patients. Nagoya University 2016-08 /pmc/articles/PMC4995277/ /pubmed/27578915 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
Tomida, Masashi
Okudaira, Kuniyasu
Kamomae, Takeshi
Oguchi, Hiroshi
Miyake, Yoshikazu
Yoneda, Kazuo
Itoh, Yoshiyuki
Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title_full Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title_fullStr Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title_full_unstemmed Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title_short Relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for Japanese patients with prostate cancer
title_sort relationship between prostate volume changes and treatment duration of neoadjuvant androgen deprivation during intensity-modulated radiation therapy for japanese patients with prostate cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995277/
https://www.ncbi.nlm.nih.gov/pubmed/27578915
work_keys_str_mv AT tomidamasashi relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT okudairakuniyasu relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT kamomaetakeshi relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT oguchihiroshi relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT miyakeyoshikazu relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT yonedakazuo relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer
AT itohyoshiyuki relationshipbetweenprostatevolumechangesandtreatmentdurationofneoadjuvantandrogendeprivationduringintensitymodulatedradiationtherapyforjapanesepatientswithprostatecancer