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COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy

The patient was a 72 year old man who had been given non-steroidal anti-inflammatory drug (NSAID) for two years. He repeatedly developed small intestinal ileus; therefore, he underwent several imaging examinations, but the cause was not identified. He subsequently underwent a double-balloon endoscop...

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Autores principales: Ueno, Yasuaki, Nakamura, Masanao, Watanabe, Osamu, Yamamura, Takeshi, Funasaka, Kohei, Ohno, Eizaburo, Miyahara, Ryoji, Kawashima, Hiroki, Goto, Hidemi, Hirooka, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2016
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995278/
https://www.ncbi.nlm.nih.gov/pubmed/27578916
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author Ueno, Yasuaki
Nakamura, Masanao
Watanabe, Osamu
Yamamura, Takeshi
Funasaka, Kohei
Ohno, Eizaburo
Miyahara, Ryoji
Kawashima, Hiroki
Goto, Hidemi
Hirooka, Yoshiki
author_facet Ueno, Yasuaki
Nakamura, Masanao
Watanabe, Osamu
Yamamura, Takeshi
Funasaka, Kohei
Ohno, Eizaburo
Miyahara, Ryoji
Kawashima, Hiroki
Goto, Hidemi
Hirooka, Yoshiki
author_sort Ueno, Yasuaki
collection PubMed
description The patient was a 72 year old man who had been given non-steroidal anti-inflammatory drug (NSAID) for two years. He repeatedly developed small intestinal ileus; therefore, he underwent several imaging examinations, but the cause was not identified. He subsequently underwent a double-balloon endoscopy (DBE). The membranous stenoses were detected in the jejunum, and the biopsy specimens were taken during the DBE. The membranous stenoses in the gastrointestinal tract were characteristic of NSAID–induced enteropathy, and he was endoscopically and histopathologically diagnosed with NSAID-induced small intestinal disorder. NSAID administration was withdrawn, and the balloon dilation was conducted for small intestinal stenosis. After that, no small intestinal ileus developed again. Some studies were conducted on the mechanism of NSAID-induced small intestinal dysfunction, but the drug that was administered to the patient was a highly selective NSAID for cyclooxygenase (COX)-2, and there are few studies that reported a dysfunctional mechanism induced by this drug. In the tissue sampled by DBE, apoptotic bodies were found; therefore, it was suggested that the stenoses in this case were caused by the COX-2 inhibitor from the relationship between COX-2 inhibition and apoptosis. Further studies are necessary to investigate the mechanism of NSAID enteropathy.
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spelling pubmed-49952782016-08-30 COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy Ueno, Yasuaki Nakamura, Masanao Watanabe, Osamu Yamamura, Takeshi Funasaka, Kohei Ohno, Eizaburo Miyahara, Ryoji Kawashima, Hiroki Goto, Hidemi Hirooka, Yoshiki Nagoya J Med Sci Case Report The patient was a 72 year old man who had been given non-steroidal anti-inflammatory drug (NSAID) for two years. He repeatedly developed small intestinal ileus; therefore, he underwent several imaging examinations, but the cause was not identified. He subsequently underwent a double-balloon endoscopy (DBE). The membranous stenoses were detected in the jejunum, and the biopsy specimens were taken during the DBE. The membranous stenoses in the gastrointestinal tract were characteristic of NSAID–induced enteropathy, and he was endoscopically and histopathologically diagnosed with NSAID-induced small intestinal disorder. NSAID administration was withdrawn, and the balloon dilation was conducted for small intestinal stenosis. After that, no small intestinal ileus developed again. Some studies were conducted on the mechanism of NSAID-induced small intestinal dysfunction, but the drug that was administered to the patient was a highly selective NSAID for cyclooxygenase (COX)-2, and there are few studies that reported a dysfunctional mechanism induced by this drug. In the tissue sampled by DBE, apoptotic bodies were found; therefore, it was suggested that the stenoses in this case were caused by the COX-2 inhibitor from the relationship between COX-2 inhibition and apoptosis. Further studies are necessary to investigate the mechanism of NSAID enteropathy. Nagoya University 2016-08 /pmc/articles/PMC4995278/ /pubmed/27578916 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ueno, Yasuaki
Nakamura, Masanao
Watanabe, Osamu
Yamamura, Takeshi
Funasaka, Kohei
Ohno, Eizaburo
Miyahara, Ryoji
Kawashima, Hiroki
Goto, Hidemi
Hirooka, Yoshiki
COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title_full COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title_fullStr COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title_full_unstemmed COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title_short COX-2 inhibitory NSAID-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
title_sort cox-2 inhibitory nsaid-induced multiple stenosis in the small intestine diagnosed by double-balloon endoscopy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995278/
https://www.ncbi.nlm.nih.gov/pubmed/27578916
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