Cargando…

TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21

TGF-β1, upregulated in keloid tissue, promotes the proliferation, collagen formation and differentiation of dermal fibroblasts. miR-21 is one of microRNAs first found in human genome. The aim of our study is to explore the mechanisms of miR-21 in TGF-β1-induced scar fibroblasts proliferation and tra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Ying, Li, Yue, Li, Ning, Teng, Wen, Wang, Min, Zhang, Yingbo, Xiao, Zhibo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995376/ https://www.ncbi.nlm.nih.gov/pubmed/27554193 http://dx.doi.org/10.1038/srep32231

Ejemplares similares

MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury
por: Wang, Wenzhao, et al.
Publicado: (2018)

MicroRNA-21 Regulates hTERT via PTEN in Hypertrophic Scar Fibroblasts
por: Zhu, Hua-Yu, et al.
Publicado: (2014)

microRNA induced transdifferentiation
por: Shenoy, Archana, et al.
Publicado: (2012)

MicroRNA-375 prevents TGF-β-dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway
por: Zhang, Xinghua, et al.
Publicado: (2020)

Nintedanib inhibits TGF-β-induced myofibroblast transdifferentiation in human Tenon’s fibroblasts
por: Lin, Xianchai, et al.
Publicado: (2018)

TGF-β-induced interleukin-6 participates in transdifferentiation of human Tenon’s fibroblasts to myofibroblasts
por: Seong, Gong Je, et al.
Publicado: (2009)

MicroRNA-663 regulates the proliferation of fibroblasts in hypertrophic scars via transforming growth factor-β1
por: Chen, Qi, et al.
Publicado: (2018)

The Role of Focal Adhesion Kinase in the TGF-β-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts
por: Hong, Samin, et al.
Publicado: (2012)

MEK inhibition prevents TGF-β1-induced myofibroblast transdifferentiation in human tenon fibroblasts
por: Wen, Jiamin, et al.
Publicado: (2019)

MicroRNA expression signature and the therapeutic effect of the microRNA-21 antagomir in hypertrophic scarring
por: Guo, Liang, et al.
Publicado: (2017)

MicroRNA-98 inhibits the cell proliferation of human hypertrophic scar fibroblasts via targeting Col1A1
por: Bi, Sheng, et al.
Publicado: (2017)

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
por: Zhang, Lijun, et al.
Publicado: (2015)

Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage
por: Christoforou, Nicolas, et al.
Publicado: (2017)

MicroRNA-9-5p inhibits proliferation and induces apoptosis of human hypertrophic scar fibroblasts through targeting peroxisome proliferator-activated receptor β
por: Chai, Chi-Yung, et al.
Publicado: (2020)

Inhibition of microRNA-21 decreases the invasiveness of fibroblast-like synoviocytes in rheumatoid arthritis via TGF(β)/Smads signaling pathway
por: Xiong, Gaoxin, et al.
Publicado: (2016)

MicroRNA-22 Can Reduce Parathymosin Expression in Transdifferentiated Hepatocytes
por: Chen, Hung-Lin, et al.
Publicado: (2012)

MicroRNA-222 regulates the viability of fibroblasts in hypertrophic scars via matrix metalloproteinase 1
por: Zhang, Yi, et al.
Publicado: (2018)

MicroRNA-18a-5p represses scar fibroblast proliferation and extracellular matrix deposition through regulating Smad2 expression
por: Li, Tianshi, et al.
Publicado: (2021)

MicroRNA-153 Inhibits Osteosarcoma Cells Proliferation and Invasion by Targeting TGF-β2
por: Niu, Guangfeng, et al.
Publicado: (2015)

Melatonin ameliorates renal fibroblast‐myofibroblast transdifferentiation and renal fibrosis through miR‐21‐5p regulation
por: Li, Ningning, et al.
Publicado: (2020)

MicroRNA-182-5p Inhibits Hypertrophic Scar Formation by Inhibiting the Proliferation and Migration of Fibroblasts via SMAD4 Pathway
por: Jin, Mingzhu, et al.
Publicado: (2023)

Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts
por: Zhai, Xiao-Xiang, et al.
Publicado: (2017)

MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression
por: Li, Chang, et al.
Publicado: (2016)

MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFβ signaling pathway
por: LIU, TIANMING, et al.
Publicado: (2015)

MicroRNA-185 regulates transforming growth factor-β1 and collagen-1 in hypertrophic scar fibroblasts
por: Xiao, Kaiyan, et al.
Publicado: (2017)

USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar–Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro
por: Tu, Longxiang, et al.
Publicado: (2021)

TGF-β1 Induced Transdifferentiation of RPE Cells is Mediated by TAK1
por: Dvashi, Zeev, et al.
Publicado: (2015)

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation
por: Schaub, Johanna R., et al.
Publicado: (2018)

microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling
por: Liu, Ronghan, et al.
Publicado: (2018)

Correction: MicroRNA-21 promotes TGF-β1-induced epithelial-mesenchymal transition in gastric cancer through up-regulating PTEN expression
por: Li, Chang, et al.
Publicado: (2020)

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts
por: Razdan, Neetu, et al.
Publicado: (2018)

MicroRNA-21 inhibits mitochondria-mediated apoptosis in keloid
por: Wu, Hao, et al.
Publicado: (2017)

Function analysis of differentially expressed microRNAs in TGF-β1-induced cardiac fibroblasts differentiation
por: Liu, Suxuan, et al.
Publicado: (2019)

MicroRNA-21 in Pancreatic Ductal Adenocarcinoma Tumor-Associated Fibroblasts Promotes Metastasis
por: Kadera, Brian E., et al.
Publicado: (2013)

MicroRNA Control of TGF-β Signaling
por: Suzuki, Hiroshi I.
Publicado: (2018)

MicroRNA-21 in cancer-associated fibroblasts supports lung adenocarcinoma progression
por: Kunita, Akiko, et al.
Publicado: (2018)

Exon skipping of TGFβRI affects signalling and ECM expression in hypertrophic scar-derived fibroblasts
por: Raktoe, Rajiv S, et al.
Publicado: (2020)

Abstract 2: Epigenetic Modulation of TGF-beta Signaling Underlies the Scarring Fibroblast Phenotype
por: desJardins-Park, Heather E., et al.
Publicado: (2019)

Functional skeletal muscle constructs from transdifferentiated human fibroblasts
por: Xu, Bin, et al.
Publicado: (2020)

MicroRNA-564 is downregulated in glioblastoma and inhibited proliferation and invasion of glioblastoma cells by targeting TGF-β1
por: Jiang, Chunming, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_19btajs7c1r6i2jg5c4surceq3