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Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus
Duck plague caused by duck plague virus (DPV) is an acute and contagious disease. To better understand the pathogenic mechanism of duck plague virus in ducklings, an infection experiment was performed. Our results showed that typical symptoms were observed in the infected ducklings. DPV could replic...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995378/ https://www.ncbi.nlm.nih.gov/pubmed/27553496 http://dx.doi.org/10.1038/srep32183 |
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author | Li, Ning Hong, Tianqi Li, Rong Guo, Mengjiao Wang, Yao Zhang, Jinzhou Liu, Jiyuan Cai, Yumei Liu, Sidang Chai, Tongjie Wei, Liangmeng |
author_facet | Li, Ning Hong, Tianqi Li, Rong Guo, Mengjiao Wang, Yao Zhang, Jinzhou Liu, Jiyuan Cai, Yumei Liu, Sidang Chai, Tongjie Wei, Liangmeng |
author_sort | Li, Ning |
collection | PubMed |
description | Duck plague caused by duck plague virus (DPV) is an acute and contagious disease. To better understand the pathogenic mechanism of duck plague virus in ducklings, an infection experiment was performed. Our results showed that typical symptoms were observed in the infected ducklings. DPV could replicate quickly in many tissues, leading to pathological lesions, especially on the spleen. Real-time quantitative PCR demonstrated that expression of many innate immune-related genes was mostly up-regulated in the brain, and the antiviral innate immune response was established, but not sufficient to restrict viral replication. In contrast, although the expression of many major pattern recognition receptors (PRRs) increased in the spleen, the expression of most cytokines was declined. Our study indicates that DPV is a pantropic virus that can replicate rapidly in tissues, causing serious pathological lesions but the immune responses are different in the spleen and brain. To our knowledge, this is the first report to systematically explore the expression profiles of the immune genes in the DPV-infected ducks. Our data provide a foundation for further study of the pathogenicity of duck plague. |
format | Online Article Text |
id | pubmed-4995378 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49953782016-08-30 Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus Li, Ning Hong, Tianqi Li, Rong Guo, Mengjiao Wang, Yao Zhang, Jinzhou Liu, Jiyuan Cai, Yumei Liu, Sidang Chai, Tongjie Wei, Liangmeng Sci Rep Article Duck plague caused by duck plague virus (DPV) is an acute and contagious disease. To better understand the pathogenic mechanism of duck plague virus in ducklings, an infection experiment was performed. Our results showed that typical symptoms were observed in the infected ducklings. DPV could replicate quickly in many tissues, leading to pathological lesions, especially on the spleen. Real-time quantitative PCR demonstrated that expression of many innate immune-related genes was mostly up-regulated in the brain, and the antiviral innate immune response was established, but not sufficient to restrict viral replication. In contrast, although the expression of many major pattern recognition receptors (PRRs) increased in the spleen, the expression of most cytokines was declined. Our study indicates that DPV is a pantropic virus that can replicate rapidly in tissues, causing serious pathological lesions but the immune responses are different in the spleen and brain. To our knowledge, this is the first report to systematically explore the expression profiles of the immune genes in the DPV-infected ducks. Our data provide a foundation for further study of the pathogenicity of duck plague. Nature Publishing Group 2016-08-24 /pmc/articles/PMC4995378/ /pubmed/27553496 http://dx.doi.org/10.1038/srep32183 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Ning Hong, Tianqi Li, Rong Guo, Mengjiao Wang, Yao Zhang, Jinzhou Liu, Jiyuan Cai, Yumei Liu, Sidang Chai, Tongjie Wei, Liangmeng Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title | Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title_full | Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title_fullStr | Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title_full_unstemmed | Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title_short | Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus |
title_sort | pathogenicity of duck plague and innate immune responses of the cherry valley ducks to duck plague virus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995378/ https://www.ncbi.nlm.nih.gov/pubmed/27553496 http://dx.doi.org/10.1038/srep32183 |
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