Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation

Glucocorticoid-induced osteoporosis (GIO) is one of the major side effects of long-term glucocorticoid (GC) therapy mediated mainly via the suppression of bone formation and osteoblast differentiation independently of GC receptor (GR) dimerization. Since microRNAs play a critical role in osteoblast...

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Detalles Bibliográficos
Autores principales: Liu, Peng, Baumgart, Mario, Groth, Marco, Wittmann, Jürgen, Jäck, Hans-Martin, Platzer, Matthias, Tuckermann, Jan P., Baschant, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995469/
https://www.ncbi.nlm.nih.gov/pubmed/27554624
http://dx.doi.org/10.1038/srep32112

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