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Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2
Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients’ group. Here we explored the association among plasm...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995470/ https://www.ncbi.nlm.nih.gov/pubmed/27554830 http://dx.doi.org/10.1038/srep32116 |
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author | Shen, Jiayun Shang, Qing Wong, Chun-Kwok Li, Edmund K. Kun, Emily W. Cheng, Isaac T. Li, Martin Li, Tena K. Zhu, Tracy Y. Yu, Cheuk-Man Qin, Ling Tam, Lai-Shan |
author_facet | Shen, Jiayun Shang, Qing Wong, Chun-Kwok Li, Edmund K. Kun, Emily W. Cheng, Isaac T. Li, Martin Li, Tena K. Zhu, Tracy Y. Yu, Cheuk-Man Qin, Ling Tam, Lai-Shan |
author_sort | Shen, Jiayun |
collection | PubMed |
description | Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients’ group. Here we explored the association among plasma levels of IL-33 and its decoy receptor soluble ST2 (sST2), carotid plaque determined by ultrasound, and volumetric bone mineral density (vBMD)/microstructure of distal radius measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) in 80 PsA patients (55% male; 53.0 ± 10.1 years). Plasma sST2 levels were significantly higher in 33 (41%) patients with carotid plaques (11.2 ± 4.5 vs 7.7 ± 3.7 ng/ml, P < 0.001). In multivariate analysis, sST2 was an independent explanatory variable associated with carotid plaques (OR = 1.296, 95% CI: [1.091,1.540]; P = 0.003). After adjustment for the osteoporotic risk factors, sST2 was significantly associated with higher cortical porosity (β = 0.184, [0.042,0.325]; P = 0.012) and cortical pore volume (2.247, [0.434,4.060]; P = 0.016); and had a trend to be associated with lower cortical vBMD (−2.918, [−6.111,0.275]; P = 0.073). IL-33 was not associated with carotid plaque or vBMD/microstructure. In conclusion, plasma sST2 levels were independently correlated with both carotid plaque and compromised cortical vBMD/microstructure in PsA patients. IL-33/ST2 axis may be a link between accelerated atherosclerosis and osteoporosis in PsA. |
format | Online Article Text |
id | pubmed-4995470 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49954702016-08-30 Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 Shen, Jiayun Shang, Qing Wong, Chun-Kwok Li, Edmund K. Kun, Emily W. Cheng, Isaac T. Li, Martin Li, Tena K. Zhu, Tracy Y. Yu, Cheuk-Man Qin, Ling Tam, Lai-Shan Sci Rep Article Psoriatic arthritis (PsA) patients have increased risk of both atherosclerosis and osteoporosis. Previous studies revealed that IL-33/ST2 axis may be related to both conditions; however, these associations were never evaluated in a single patients’ group. Here we explored the association among plasma levels of IL-33 and its decoy receptor soluble ST2 (sST2), carotid plaque determined by ultrasound, and volumetric bone mineral density (vBMD)/microstructure of distal radius measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) in 80 PsA patients (55% male; 53.0 ± 10.1 years). Plasma sST2 levels were significantly higher in 33 (41%) patients with carotid plaques (11.2 ± 4.5 vs 7.7 ± 3.7 ng/ml, P < 0.001). In multivariate analysis, sST2 was an independent explanatory variable associated with carotid plaques (OR = 1.296, 95% CI: [1.091,1.540]; P = 0.003). After adjustment for the osteoporotic risk factors, sST2 was significantly associated with higher cortical porosity (β = 0.184, [0.042,0.325]; P = 0.012) and cortical pore volume (2.247, [0.434,4.060]; P = 0.016); and had a trend to be associated with lower cortical vBMD (−2.918, [−6.111,0.275]; P = 0.073). IL-33 was not associated with carotid plaque or vBMD/microstructure. In conclusion, plasma sST2 levels were independently correlated with both carotid plaque and compromised cortical vBMD/microstructure in PsA patients. IL-33/ST2 axis may be a link between accelerated atherosclerosis and osteoporosis in PsA. Nature Publishing Group 2016-08-24 /pmc/articles/PMC4995470/ /pubmed/27554830 http://dx.doi.org/10.1038/srep32116 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Shen, Jiayun Shang, Qing Wong, Chun-Kwok Li, Edmund K. Kun, Emily W. Cheng, Isaac T. Li, Martin Li, Tena K. Zhu, Tracy Y. Yu, Cheuk-Man Qin, Ling Tam, Lai-Shan Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title | Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title_full | Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title_fullStr | Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title_full_unstemmed | Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title_short | Carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble ST2 |
title_sort | carotid plaque and bone density and microarchitecture in psoriatic arthritis: the correlation with soluble st2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995470/ https://www.ncbi.nlm.nih.gov/pubmed/27554830 http://dx.doi.org/10.1038/srep32116 |
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