Matrix metalloproteinase-1 induction by diethyldithiocarbamate is regulated via Akt and ERK/miR222/ETS-1 pathways in hepatic stellate cells

Matrix metalloproteinase-1 (MMP-1) plays an important role in fibrolysis by degrading excessively deposited collagen I and III. We previously demonstrated that diethyldithiocarbamate (DDC) up-regulates MMP-1 in hepatic stellate cells via the ERK1/2 and Akt signalling pathways. In the current study,...

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Detalles Bibliográficos
Autores principales: Liu, Tianhui, Wang, Ping, Cong, Min, Zhang, Dong, Liu, Lin, Li, Hongyi, Zhai, Qingling, Li, Zhuo, Jia, Jidong, You, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995499/
https://www.ncbi.nlm.nih.gov/pubmed/27412967
http://dx.doi.org/10.1042/BSR20160111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995499/
https://www.ncbi.nlm.nih.gov/pubmed/27412967
http://dx.doi.org/10.1042/BSR20160111

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