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Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths

BACKGROUND: Post-traumatic stress disorder (PTSD) psychotherapy research has failed to identify patient characteristics that consistently predict differential outcome. AIMS: To identify patient characteristics associated with differential outcome via a statistically generated composite moderator amo...

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Autores principales: Cloitre, Marylene, Petkova, Eva, Su, Zhe, Weiss, Brandon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal College of Psychiatrists 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995554/
https://www.ncbi.nlm.nih.gov/pubmed/27703762
http://dx.doi.org/10.1192/bjpo.bp.115.000745
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author Cloitre, Marylene
Petkova, Eva
Su, Zhe
Weiss, Brandon
author_facet Cloitre, Marylene
Petkova, Eva
Su, Zhe
Weiss, Brandon
author_sort Cloitre, Marylene
collection PubMed
description BACKGROUND: Post-traumatic stress disorder (PTSD) psychotherapy research has failed to identify patient characteristics that consistently predict differential outcome. AIMS: To identify patient characteristics associated with differential outcome via a statistically generated composite moderator among women with childhood abuse-related PTSD in a randomised controlled trial comparing exposure therapy, skills training and their combination. METHOD: Six baseline patient characteristics were combined in a composite moderator of treatment effects for PTSD symptoms across the three treatment conditions through a 6-month follow-up. RESULTS: The optimal moderator was the combined burden of all symptoms and emotion regulation strength. Those with high moderator scores, reflecting high symptom load relative to emotion regulation, did least well in exposure, moderately well in skills and best in the combination. CONCLUSIONS: A clinically meaningful moderator, which combines patient symptom burden and strengths, was identified. Assessment at follow-up may provide a more accurate indicator of variability in outcome than that obtained immediately post-treatment. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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spelling pubmed-49955542016-10-04 Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths Cloitre, Marylene Petkova, Eva Su, Zhe Weiss, Brandon BJPsych Open Paper BACKGROUND: Post-traumatic stress disorder (PTSD) psychotherapy research has failed to identify patient characteristics that consistently predict differential outcome. AIMS: To identify patient characteristics associated with differential outcome via a statistically generated composite moderator among women with childhood abuse-related PTSD in a randomised controlled trial comparing exposure therapy, skills training and their combination. METHOD: Six baseline patient characteristics were combined in a composite moderator of treatment effects for PTSD symptoms across the three treatment conditions through a 6-month follow-up. RESULTS: The optimal moderator was the combined burden of all symptoms and emotion regulation strength. Those with high moderator scores, reflecting high symptom load relative to emotion regulation, did least well in exposure, moderately well in skills and best in the combination. CONCLUSIONS: A clinically meaningful moderator, which combines patient symptom burden and strengths, was identified. Assessment at follow-up may provide a more accurate indicator of variability in outcome than that obtained immediately post-treatment. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence. The Royal College of Psychiatrists 2016-03-02 /pmc/articles/PMC4995554/ /pubmed/27703762 http://dx.doi.org/10.1192/bjpo.bp.115.000745 Text en © 2016 The Royal College of Psychiatrists http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Paper
Cloitre, Marylene
Petkova, Eva
Su, Zhe
Weiss, Brandon
Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title_full Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title_fullStr Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title_full_unstemmed Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title_short Patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
title_sort patient characteristics as a moderator of post-traumatic stress disorder treatment outcome: combining symptom burden and strengths
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995554/
https://www.ncbi.nlm.nih.gov/pubmed/27703762
http://dx.doi.org/10.1192/bjpo.bp.115.000745
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