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Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort

BACKGROUND: Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to af...

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Autores principales: Lyall, Donald M., Inskip, Hazel M., Mackay, Daniel, Deary, Ian J., McIntosh, Andrew M., Hotopf, Matthew, Kendrick, Tony, Pell, Jill P., Smith, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal College of Psychiatrists 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995581/
https://www.ncbi.nlm.nih.gov/pubmed/27703752
http://dx.doi.org/10.1192/bjpo.bp.115.002154
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author Lyall, Donald M.
Inskip, Hazel M.
Mackay, Daniel
Deary, Ian J.
McIntosh, Andrew M.
Hotopf, Matthew
Kendrick, Tony
Pell, Jill P.
Smith, Daniel J.
author_facet Lyall, Donald M.
Inskip, Hazel M.
Mackay, Daniel
Deary, Ian J.
McIntosh, Andrew M.
Hotopf, Matthew
Kendrick, Tony
Pell, Jill P.
Smith, Daniel J.
author_sort Lyall, Donald M.
collection PubMed
description BACKGROUND: Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. AIMS: To assess whether very low birth weight (<1500 g) and low birth weight (1500–2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD. We controlled for possible confounding factors. METHOD: Retrospective cohort study using baseline data on the 83 545 UK Biobank participants with detailed mental health and birth weight data. Main outcomes were prevalent MDD and BD, and neuroticism assessed using the Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R) RESULTS: Referent to normal birth weight, very low/low birth weight were associated with higher neuroticism scores, increased MDD and BD. The associations between birth weight category and MDD were partially mediated by higher neuroticism. CONCLUSIONS: These findings suggest that intrauterine programming may play a role in lifetime vulnerability to affective disorders. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
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spelling pubmed-49955812016-10-04 Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort Lyall, Donald M. Inskip, Hazel M. Mackay, Daniel Deary, Ian J. McIntosh, Andrew M. Hotopf, Matthew Kendrick, Tony Pell, Jill P. Smith, Daniel J. BJPsych Open Paper BACKGROUND: Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. AIMS: To assess whether very low birth weight (<1500 g) and low birth weight (1500–2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD. We controlled for possible confounding factors. METHOD: Retrospective cohort study using baseline data on the 83 545 UK Biobank participants with detailed mental health and birth weight data. Main outcomes were prevalent MDD and BD, and neuroticism assessed using the Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R) RESULTS: Referent to normal birth weight, very low/low birth weight were associated with higher neuroticism scores, increased MDD and BD. The associations between birth weight category and MDD were partially mediated by higher neuroticism. CONCLUSIONS: These findings suggest that intrauterine programming may play a role in lifetime vulnerability to affective disorders. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence. The Royal College of Psychiatrists 2016-01-28 /pmc/articles/PMC4995581/ /pubmed/27703752 http://dx.doi.org/10.1192/bjpo.bp.115.002154 Text en © 2016 The Royal College of Psychiatrists http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Paper
Lyall, Donald M.
Inskip, Hazel M.
Mackay, Daniel
Deary, Ian J.
McIntosh, Andrew M.
Hotopf, Matthew
Kendrick, Tony
Pell, Jill P.
Smith, Daniel J.
Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title_full Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title_fullStr Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title_full_unstemmed Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title_short Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
title_sort low birth weight and features of neuroticism and mood disorder in 83 545 participants of the uk biobank cohort
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995581/
https://www.ncbi.nlm.nih.gov/pubmed/27703752
http://dx.doi.org/10.1192/bjpo.bp.115.002154
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