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Results of an attempt to reproduce the STAP phenomenon

In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to c...

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Autor principal: Aizawa, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995676/
https://www.ncbi.nlm.nih.gov/pubmed/27610221
http://dx.doi.org/10.12688/f1000research.8731.2
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author Aizawa, Shinichi
author_facet Aizawa, Shinichi
author_sort Aizawa, Shinichi
collection PubMed
description In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation. Here, I report the results of an attempt by Haruko Obokata to replicate the phenomenon under the supervision of the Scientific Validity Examination Team of RIKEN. In this follow-up study, putative STAP cells prepared by Haruko Obokata were injected into 1051 embryos, of which 591 were recovered. However, the injected cells made no significant contribution in any of the embryos that developed.
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spelling pubmed-49956762016-09-07 Results of an attempt to reproduce the STAP phenomenon Aizawa, Shinichi F1000Res Research Article In 2014, Obokata and colleagues reported their observation of a novel cell reprogramming phenomenon they named ‘stimulus-triggered acquisition of pluripotency’ (STAP). The most conclusive evidence for the pluripotency of so-called STAP cells was the purported ability of such cells to contribute to chimera formation. Here, I report the results of an attempt by Haruko Obokata to replicate the phenomenon under the supervision of the Scientific Validity Examination Team of RIKEN. In this follow-up study, putative STAP cells prepared by Haruko Obokata were injected into 1051 embryos, of which 591 were recovered. However, the injected cells made no significant contribution in any of the embryos that developed. F1000Research 2016-10-17 /pmc/articles/PMC4995676/ /pubmed/27610221 http://dx.doi.org/10.12688/f1000research.8731.2 Text en Copyright: © 2016 Aizawa S http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Aizawa, Shinichi
Results of an attempt to reproduce the STAP phenomenon
title Results of an attempt to reproduce the STAP phenomenon
title_full Results of an attempt to reproduce the STAP phenomenon
title_fullStr Results of an attempt to reproduce the STAP phenomenon
title_full_unstemmed Results of an attempt to reproduce the STAP phenomenon
title_short Results of an attempt to reproduce the STAP phenomenon
title_sort results of an attempt to reproduce the stap phenomenon
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995676/
https://www.ncbi.nlm.nih.gov/pubmed/27610221
http://dx.doi.org/10.12688/f1000research.8731.2
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