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An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells

After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule inhibition of PARG has been a goal for many ye...

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Detalles Bibliográficos
Autores principales:	James, Dominic I., Durant, Stephen, Eckersley, Kay, Fairweather, Emma, Griffiths, Louise A., Hamilton, Nicola, Kelly, Paul, O'Connor, Mark, Shea, Kerry, Waddell, Ian D., Ogilvie, Donald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2016
Materias:	Method Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995692/ https://www.ncbi.nlm.nih.gov/pubmed/27610220 http://dx.doi.org/10.12688/f1000research.8463.2

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