The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma

The Hippo effector YAP has recently been identified as a potent driver of embryonal rhabdomyosarcoma (ERMS). Most reports suggest that the YAP paralogue TAZ (gene symbol WWTR1) functions as YAP but, in skeletal muscle, TAZ has been reported to promote myogenic differentiation, whereas YAP inhibits i...

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Detalles Bibliográficos
Autores principales: Mohamed, Abdalla, Sun, Congshan, De Mello, Vanessa, Selfe, Joanna, Missiaglia, Edoardo, Shipley, Janet, Murray, Graeme I, Zammit, Pete S, Wackerhage, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995731/
https://www.ncbi.nlm.nih.gov/pubmed/27184927
http://dx.doi.org/10.1002/path.4745

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