Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma

We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR...

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Autores principales: Qing, Kai, Jin, Zhen, Fu, Wanbin, Wang, Wenfang, Liu, Zhao, Li, Xiaoyang, Xu, Zizhen, Li, Junmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995739/
https://www.ncbi.nlm.nih.gov/pubmed/27554093
http://dx.doi.org/10.1186/s13045-016-0303-0
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author Qing, Kai
Jin, Zhen
Fu, Wanbin
Wang, Wenfang
Liu, Zhao
Li, Xiaoyang
Xu, Zizhen
Li, Junmin
author_facet Qing, Kai
Jin, Zhen
Fu, Wanbin
Wang, Wenfang
Liu, Zhao
Li, Xiaoyang
Xu, Zizhen
Li, Junmin
author_sort Qing, Kai
collection PubMed
description We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage response. Our findings pave the way for a new potential treatment option for non-GCB DLBCL with the combination of oridonin and NVP-BEZ235. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-016-0303-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-49957392016-08-25 Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma Qing, Kai Jin, Zhen Fu, Wanbin Wang, Wenfang Liu, Zhao Li, Xiaoyang Xu, Zizhen Li, Junmin J Hematol Oncol Letter to the Editor We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mechanism may be multifunctional, involving apoptosis, AKT/mTOR and NF-kB inactivation, and ROS-mediated DNA damage response. Our findings pave the way for a new potential treatment option for non-GCB DLBCL with the combination of oridonin and NVP-BEZ235. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13045-016-0303-0) contains supplementary material, which is available to authorized users. BioMed Central 2016-08-23 /pmc/articles/PMC4995739/ /pubmed/27554093 http://dx.doi.org/10.1186/s13045-016-0303-0 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Qing, Kai
Jin, Zhen
Fu, Wanbin
Wang, Wenfang
Liu, Zhao
Li, Xiaoyang
Xu, Zizhen
Li, Junmin
Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title_full Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title_fullStr Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title_full_unstemmed Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title_short Synergistic effect of oridonin and a PI3K/mTOR inhibitor on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma
title_sort synergistic effect of oridonin and a pi3k/mtor inhibitor on the non-germinal center b cell-like subtype of diffuse large b cell lymphoma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995739/
https://www.ncbi.nlm.nih.gov/pubmed/27554093
http://dx.doi.org/10.1186/s13045-016-0303-0
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