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Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings

BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also...

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Autores principales: Mokhtari, Maral, Kumar, Perikala Vijayananda, Hayati, Kamran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995867/
https://www.ncbi.nlm.nih.gov/pubmed/27756982
http://dx.doi.org/10.4103/0970-9371.188046
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author Mokhtari, Maral
Kumar, Perikala Vijayananda
Hayati, Kamran
author_facet Mokhtari, Maral
Kumar, Perikala Vijayananda
Hayati, Kamran
author_sort Mokhtari, Maral
collection PubMed
description BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid lesions. MATERIALS AND METHODS: Seventy-three cases of CPTC were included in the study. The cytomorphologic features of these cases were analyzed. The FNA smears of other thyroid lesions with cystic changes (300 colloid goiters, 290 adenomatoid nodules, 11 follicular neoplasms, and 9 hurtle cell neoplasm) were also studied. RESULTS: The smears in CPTC revealed isolated follicular cells, small groups of cells with scalloped margins, cell swirls, small clusters with a cartwheel pattern, papillary clusters, intranuclear inclusions, nuclear grooves, sticky colloid, intracellular colloids, psammoma bodies, multinucleated giant cells, and foamy and hemosiderin laden macrophages. Small groups of cells with scalloped borders, cellular swirls, and small clusters with a cartwheel pattern were seen in CPTC, but not in other cystic lesions. Interestingly, mesothelial-like cells and hemophagocytic cells were seen in five and three cases of CPTC, respectively, but not in other cystic lesions. CONCLUSION: Mesothelial-like cells and hemophagocytic cells were observed in five and three cases of CPTC, respectively. Similar finding have not been previously reported in the literature.
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spelling pubmed-49958672016-10-18 Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings Mokhtari, Maral Kumar, Perikala Vijayananda Hayati, Kamran J Cytol Original Article BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid lesions. MATERIALS AND METHODS: Seventy-three cases of CPTC were included in the study. The cytomorphologic features of these cases were analyzed. The FNA smears of other thyroid lesions with cystic changes (300 colloid goiters, 290 adenomatoid nodules, 11 follicular neoplasms, and 9 hurtle cell neoplasm) were also studied. RESULTS: The smears in CPTC revealed isolated follicular cells, small groups of cells with scalloped margins, cell swirls, small clusters with a cartwheel pattern, papillary clusters, intranuclear inclusions, nuclear grooves, sticky colloid, intracellular colloids, psammoma bodies, multinucleated giant cells, and foamy and hemosiderin laden macrophages. Small groups of cells with scalloped borders, cellular swirls, and small clusters with a cartwheel pattern were seen in CPTC, but not in other cystic lesions. Interestingly, mesothelial-like cells and hemophagocytic cells were seen in five and three cases of CPTC, respectively, but not in other cystic lesions. CONCLUSION: Mesothelial-like cells and hemophagocytic cells were observed in five and three cases of CPTC, respectively. Similar finding have not been previously reported in the literature. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4995867/ /pubmed/27756982 http://dx.doi.org/10.4103/0970-9371.188046 Text en Copyright: © 2016 Journal of Cytology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Mokhtari, Maral
Kumar, Perikala Vijayananda
Hayati, Kamran
Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title_full Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title_fullStr Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title_full_unstemmed Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title_short Fine-needle aspiration study of cystic papillary thyroid carcinoma: Rare cytological findings
title_sort fine-needle aspiration study of cystic papillary thyroid carcinoma: rare cytological findings
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995867/
https://www.ncbi.nlm.nih.gov/pubmed/27756982
http://dx.doi.org/10.4103/0970-9371.188046
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