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The Molecular Mechanism of P2Y(1) Receptor Activation

Human purinergic G protein‐coupled receptor P2Y(1) (P2Y(1)R) is activated by adenosine 5′‐diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Crystal structures of P2Y(1)R revealed that one ligand (MRS2500) binds to the extracellular vestibu...

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Detalles Bibliográficos
Autores principales:	Yuan, Shuguang, Chan, H. C. Stephen, Vogel, Horst, Filipek, Slawomir, Stevens, Raymond C., Palczewski, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996126/ https://www.ncbi.nlm.nih.gov/pubmed/27460867 http://dx.doi.org/10.1002/anie.201605147

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