Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing

The advent of RNA-guided endonuclease (RGEN)-mediated gene editing, specifically via CRISPR/Cas9, has spurred intensive efforts to improve the efficiency of both RGEN delivery and targeted mutagenesis. The major viral vectors in use for delivery of Cas9 and its associated guide RNA, lentiviral and a...

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Detalles Bibliográficos
Autores principales: Park, Arnold, Hong, Patrick, Won, Sohui T, Thibault, Patricia A, Vigant, Frederic, Oguntuyo, Kasopefoluwa Y, Taft, Justin D, Lee, Benhur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996130/
https://www.ncbi.nlm.nih.gov/pubmed/27606350
http://dx.doi.org/10.1038/mtm.2016.57

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