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Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b-deficien...

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Detalles Bibliográficos
Autores principales:	Wang, Haibo, Han, Xiaokun, Bretz, Colin A, Becker, Silke, Gambhir, Deeksha, Smith, George W, Samulski, R Jude, Wittchen, Erika S, Quilliam, Lawrence A, Chrzanowska-Wodnicka, Magdalena, Hartnett, M Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996131/ https://www.ncbi.nlm.nih.gov/pubmed/27606349 http://dx.doi.org/10.1038/mtm.2016.56

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