Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell Clones is Defined by the Promoter CpG Methylation Pattern Observed by High-Throughput Methylation Specific Sequencing

Normal human hematopoietic stem and progenitor cells (HPC) lose expression of MLH1, an important mismatch repair (MMR) pathway gene, with age. Loss of MMR leads to replication dependent mutational events and microsatellite instability observed in secondary acute myelogenous leukemia and other hemato...

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Autores principales: Kenyon, Jonathan, Nickel-Meester, Gabrielle, Qing, Yulan, Santos-Guasch, Gabriela, Drake, Ellen, PingfuFu, Sun, Shuying, Bai, Xiaodong, Wald, David, Arts, Eric, Gerson, Stanton L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996274/
https://www.ncbi.nlm.nih.gov/pubmed/27570841

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