Aptamer-Based Screens of Human Body Fluids for Biomarkers

In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hop...

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Detalles Bibliográficos
Autores principales: Albaba, Dania, Soomro, Sanam, Mohan, Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996379/
https://www.ncbi.nlm.nih.gov/pubmed/27600232
http://dx.doi.org/10.3390/microarrays4030424
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author Albaba, Dania
Soomro, Sanam
Mohan, Chandra
author_facet Albaba, Dania
Soomro, Sanam
Mohan, Chandra
author_sort Albaba, Dania
collection PubMed
description In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered.
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spelling pubmed-49963792016-09-06 Aptamer-Based Screens of Human Body Fluids for Biomarkers Albaba, Dania Soomro, Sanam Mohan, Chandra Microarrays (Basel) Review In recent years, aptamers have come to replace antibodies in high throughput multiplexed experiments. The aptamer-based biomarker screening technology, which kicked off in 2010, is capable of interrogating thousands of proteins in a very small sample volume. With this new technology, researchers hope to find clinically appropriate biomarkers for a myriad of illnesses by screening human body fluids. In this work, we have reviewed a total of eight studies utilizing aptamer-based biomarker screens of human body fluids, and have highlighted novel protein biomarkers discovered. MDPI 2015-09-22 /pmc/articles/PMC4996379/ /pubmed/27600232 http://dx.doi.org/10.3390/microarrays4030424 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Albaba, Dania
Soomro, Sanam
Mohan, Chandra
Aptamer-Based Screens of Human Body Fluids for Biomarkers
title Aptamer-Based Screens of Human Body Fluids for Biomarkers
title_full Aptamer-Based Screens of Human Body Fluids for Biomarkers
title_fullStr Aptamer-Based Screens of Human Body Fluids for Biomarkers
title_full_unstemmed Aptamer-Based Screens of Human Body Fluids for Biomarkers
title_short Aptamer-Based Screens of Human Body Fluids for Biomarkers
title_sort aptamer-based screens of human body fluids for biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996379/
https://www.ncbi.nlm.nih.gov/pubmed/27600232
http://dx.doi.org/10.3390/microarrays4030424
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