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SNPs Array Karyotyping in Non-Hodgkin Lymphoma

The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome scree...

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Detalles Bibliográficos
Autores principales: Etebari, Maryam, Navari, Mohsen, Piccaluga, Pier Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996401/
https://www.ncbi.nlm.nih.gov/pubmed/27600240
http://dx.doi.org/10.3390/microarrays4040551
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author Etebari, Maryam
Navari, Mohsen
Piccaluga, Pier Paolo
author_facet Etebari, Maryam
Navari, Mohsen
Piccaluga, Pier Paolo
author_sort Etebari, Maryam
collection PubMed
description The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome screening at global level in order to find chromosomal aberrations like copy number variants, DNA amplifications, deletions, and also loss of heterozygosity became feasible. In this review, we present an update of the knowledge, gained by SNPs arrays, of the genomic complexity of the most important subtypes of non-Hodgkin lymphomas.
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spelling pubmed-49964012016-09-06 SNPs Array Karyotyping in Non-Hodgkin Lymphoma Etebari, Maryam Navari, Mohsen Piccaluga, Pier Paolo Microarrays (Basel) Review The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome screening at global level in order to find chromosomal aberrations like copy number variants, DNA amplifications, deletions, and also loss of heterozygosity became feasible. In this review, we present an update of the knowledge, gained by SNPs arrays, of the genomic complexity of the most important subtypes of non-Hodgkin lymphomas. MDPI 2015-11-12 /pmc/articles/PMC4996401/ /pubmed/27600240 http://dx.doi.org/10.3390/microarrays4040551 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Etebari, Maryam
Navari, Mohsen
Piccaluga, Pier Paolo
SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title_full SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title_fullStr SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title_full_unstemmed SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title_short SNPs Array Karyotyping in Non-Hodgkin Lymphoma
title_sort snps array karyotyping in non-hodgkin lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996401/
https://www.ncbi.nlm.nih.gov/pubmed/27600240
http://dx.doi.org/10.3390/microarrays4040551
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