Cargando…
SNPs Array Karyotyping in Non-Hodgkin Lymphoma
The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome scree...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996401/ https://www.ncbi.nlm.nih.gov/pubmed/27600240 http://dx.doi.org/10.3390/microarrays4040551 |
_version_ | 1782449596304195584 |
---|---|
author | Etebari, Maryam Navari, Mohsen Piccaluga, Pier Paolo |
author_facet | Etebari, Maryam Navari, Mohsen Piccaluga, Pier Paolo |
author_sort | Etebari, Maryam |
collection | PubMed |
description | The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome screening at global level in order to find chromosomal aberrations like copy number variants, DNA amplifications, deletions, and also loss of heterozygosity became feasible. In this review, we present an update of the knowledge, gained by SNPs arrays, of the genomic complexity of the most important subtypes of non-Hodgkin lymphomas. |
format | Online Article Text |
id | pubmed-4996401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49964012016-09-06 SNPs Array Karyotyping in Non-Hodgkin Lymphoma Etebari, Maryam Navari, Mohsen Piccaluga, Pier Paolo Microarrays (Basel) Review The traditional methods for detection of chromosomal aberrations, which included cytogenetic or gene candidate solutions, suffered from low sensitivity or the need for previous knowledge of the target regions of the genome. With the advent of single nucleotide polymorphism (SNP) arrays, genome screening at global level in order to find chromosomal aberrations like copy number variants, DNA amplifications, deletions, and also loss of heterozygosity became feasible. In this review, we present an update of the knowledge, gained by SNPs arrays, of the genomic complexity of the most important subtypes of non-Hodgkin lymphomas. MDPI 2015-11-12 /pmc/articles/PMC4996401/ /pubmed/27600240 http://dx.doi.org/10.3390/microarrays4040551 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Etebari, Maryam Navari, Mohsen Piccaluga, Pier Paolo SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title | SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title_full | SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title_fullStr | SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title_full_unstemmed | SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title_short | SNPs Array Karyotyping in Non-Hodgkin Lymphoma |
title_sort | snps array karyotyping in non-hodgkin lymphoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996401/ https://www.ncbi.nlm.nih.gov/pubmed/27600240 http://dx.doi.org/10.3390/microarrays4040551 |
work_keys_str_mv | AT etebarimaryam snpsarraykaryotypinginnonhodgkinlymphoma AT navarimohsen snpsarraykaryotypinginnonhodgkinlymphoma AT piccalugapierpaolo snpsarraykaryotypinginnonhodgkinlymphoma |