Cargando…

Impairment of cocaine-mediated behaviours in mice by clinically relevant Ras-ERK inhibitors

Ras-ERK signalling in the brain plays a central role in drug addiction. However, to date, no clinically relevant inhibitor of this cascade has been tested in experimental models of addiction, a necessary step toward clinical trials. We designed two new cell-penetrating peptides - RB1 and RB3 - that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Papale, Alessandro, Morella, Ilaria Maria, Indrigo, Marzia Tina, Bernardi, Rick Eugene, Marrone, Livia, Marchisella, Francesca, Brancale, Andrea, Spanagel, Rainer, Brambilla, Riccardo, Fasano, Stefania
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996650/ https://www.ncbi.nlm.nih.gov/pubmed/27557444 http://dx.doi.org/10.7554/eLife.17111

Ejemplares similares

Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice
por: Morella, Ilaria, et al.
Publicado: (2022)

Differential involvement of Ras-GRF1 and Ras-GRF2 in L-DOPA-induced dyskinesia
por: Bido, Simone, et al.
Publicado: (2015)

Ras–ERK Signaling in Behavior: Old Questions and New Perspectives
por: Fasano, Stefania, et al.
Publicado: (2011)

Sign- and goal-tracking score does not correlate with addiction-like behavior following prolonged cocaine self-administration
por: Pohořalá, Veronika, et al.
Publicado: (2021)

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2
por: Indrigo, Marzia, et al.
Publicado: (2023)

Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices
por: Morella, Ilaria, et al.
Publicado: (2020)

Dissociable Role of Corticotropin Releasing Hormone Receptor Subtype 1 on Dopaminergic and D1 Dopaminoceptive Neurons in Cocaine Seeking Behavior
por: Bernardi, Rick E., et al.
Publicado: (2017)

A Rational Design of α-Helix-Shaped Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders
por: Gulotta, Maria Rita, et al.
Publicado: (2021)

Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin
por: Ruiz-DeDiego, Irene, et al.
Publicado: (2018)

ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
por: Vantaggiato, Chiara, et al.
Publicado: (2006)

Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI
por: Cannella, Nazzareno, et al.
Publicado: (2020)

Comment on Flagel et al.: Sign-tracking as a predictor of addiction vulnerability
por: Pohořalá, Veronika, et al.
Publicado: (2021)

RAS Dimers: The Novice Couple at the RAS-ERK Pathway Ball
por: Herrero, Ana, et al.
Publicado: (2021)

Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications
por: Bilbao, Ainhoa, et al.
Publicado: (2022)

A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics
por: Rose, John C., et al.
Publicado: (2016)

On the relevance of cocaine detection in a fingerprint
por: Jang, M., et al.
Publicado: (2020)

[18F]-Fluorodeoxyglucose-Positron Emission Tomography in Rats with Prolonged Cocaine Self-Administration Suggests Potential Brain Biomarkers for Addictive Behavior
por: Cannella, Nazzareno, et al.
Publicado: (2017)

HIV-1/Cocaine Induced Oxidative Stress Disrupts Tight Junction Protein-1 in Human Pulmonary Microvascular Endothelial Cells: Role of Ras/ERK1/2 Pathway
por: Dalvi, Pranjali, et al.
Publicado: (2014)

CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects
por: Bilbao, Ainhoa, et al.
Publicado: (2014)

Mulberry polyphenol extracts attenuated senescence through inhibition of Ras/ERK via promoting Ras degradation in VSMC
por: Chen, Ching-Pei, et al.
Publicado: (2022)

Corrigendum: CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects
por: Bilbao, Ainhoa, et al.
Publicado: (2014)

DNA methylation in cocaine use disorder–An epigenome-wide approach in the human prefrontal cortex
por: Poisel, Eric, et al.
Publicado: (2023)

The metastasis suppressor Nm23 as a modulator of Ras/ERK signaling
por: Takács-Vellai, Krisztina
Publicado: (2014)

The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity
por: Slack, Cathy, et al.
Publicado: (2015)

Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs
por: Yue, Jingyin, et al.
Publicado: (2017)

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras
por: Frodyma, Danielle, et al.
Publicado: (2017)

Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
por: Gonzalez-Hormazabal, Patricio, et al.
Publicado: (2018)

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
por: Gillies, Taryn E, et al.
Publicado: (2020)

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy
por: Degirmenci, Ufuk, et al.
Publicado: (2020)

Relevance and Diversity of Nitrospira Populations in Biofilters of Brackish RAS
por: Kruse, Myriam, et al.
Publicado: (2013)

Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence
por: Menzies, Georgina E., et al.
Publicado: (2021)

Reversal of the Ras-Induced Transformed Phenotype by Hr12, a Novel Ras Farnesylation Inhibitor, Is Mediated by the Mek/ERK Pathway
por: Reuveni, Hadas, et al.
Publicado: (2000)

CARD9 mediates Dectin-1–induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity
por: Jia, Xin-Ming, et al.
Publicado: (2014)

RasGRP1, but Not RasGRP3, Is Required for Efficient Thymic β-Selection and ERK Activation Downstream of CXCR4
por: Golec, Dominic P., et al.
Publicado: (2013)

Adaptor SKAP-55 Binds p21(ras) Activating Exchange Factor RasGRP1 and Negatively Regulates the p21(ras)-ERK Pathway in T-Cells
por: Schneider, Helga, et al.
Publicado: (2008)

Circadian clock-controlled diurnal oscillation of Ras/ERK signaling in mouse liver
por: TSUCHIYA, Yoshiki, et al.
Publicado: (2013)

Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway
por: Kochetkova, Elena Y., et al.
Publicado: (2017)

Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition
por: Catalano, Antonella, et al.
Publicado: (2021)

Reusability and composability in process description maps: RAS–RAF–MEK–ERK signalling
por: Mazein, Alexander, et al.
Publicado: (2021)

Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
por: Lai, Lick Pui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m1agnos5vocpoa460mjgqq21ul