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Multiple Meningiomas in a Patient with Cowden Syndrome
BACKGROUND: Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear. CASE DESCRIPTION: We report a case of a 43-year-old...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Georg Thieme Verlag KG
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996671/ https://www.ncbi.nlm.nih.gov/pubmed/27563534 http://dx.doi.org/10.1055/s-0036-1584265 |
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author | Pain, Margaret Darbinyan, Armine Fowkes, Mary Shrivastava, Raj |
author_facet | Pain, Margaret Darbinyan, Armine Fowkes, Mary Shrivastava, Raj |
author_sort | Pain, Margaret |
collection | PubMed |
description | BACKGROUND: Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear. CASE DESCRIPTION: We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of headache demonstrated two skull base meningiomas. At the time of surgery, several additional tiny meningiomas were detected in the same region. CONCLUSIONS: The development of multiple meningiomas in a patient with predisposition for tumor is more than coincidental. Though PTEN mutations and deletions have not been shown to be critical for meningioma development, this case challenges that conclusion. In light of recent genetic advances in meningioma molecular pathogenesis, the role of the PTEN/AKT/PI3K pathway is discussed. |
format | Online Article Text |
id | pubmed-4996671 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Georg Thieme Verlag KG |
record_format | MEDLINE/PubMed |
spelling | pubmed-49966712016-08-25 Multiple Meningiomas in a Patient with Cowden Syndrome Pain, Margaret Darbinyan, Armine Fowkes, Mary Shrivastava, Raj J Neurol Surg Rep BACKGROUND: Cowden syndrome is a rare, multisystem disease manifesting with increased hamartomas and neoplasms. Though meningioma has been documented in patients with Cowden syndrome, the relationship between these two phenomena is still unclear. CASE DESCRIPTION: We report a case of a 43-year-old female patient with a known PTEN mutation and clinical history of Cowden syndrome. A workup of headache demonstrated two skull base meningiomas. At the time of surgery, several additional tiny meningiomas were detected in the same region. CONCLUSIONS: The development of multiple meningiomas in a patient with predisposition for tumor is more than coincidental. Though PTEN mutations and deletions have not been shown to be critical for meningioma development, this case challenges that conclusion. In light of recent genetic advances in meningioma molecular pathogenesis, the role of the PTEN/AKT/PI3K pathway is discussed. Georg Thieme Verlag KG 2016-07 /pmc/articles/PMC4996671/ /pubmed/27563534 http://dx.doi.org/10.1055/s-0036-1584265 Text en © Thieme Medical Publishers |
spellingShingle | Pain, Margaret Darbinyan, Armine Fowkes, Mary Shrivastava, Raj Multiple Meningiomas in a Patient with Cowden Syndrome |
title | Multiple Meningiomas in a Patient with Cowden Syndrome |
title_full | Multiple Meningiomas in a Patient with Cowden Syndrome |
title_fullStr | Multiple Meningiomas in a Patient with Cowden Syndrome |
title_full_unstemmed | Multiple Meningiomas in a Patient with Cowden Syndrome |
title_short | Multiple Meningiomas in a Patient with Cowden Syndrome |
title_sort | multiple meningiomas in a patient with cowden syndrome |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996671/ https://www.ncbi.nlm.nih.gov/pubmed/27563534 http://dx.doi.org/10.1055/s-0036-1584265 |
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