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Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain

OBJECTIVE: To determine the association between plasma brain natriuretic peptide (BNP) level in patients with heart failure (HF) and physical frailty as well as with each domain of physical frailty. METHODS: Two hundred and six outpatients of cardiovascular medicine aged 60 years and older who had b...

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Autores principales: Nishiguchi, Shu, Nozaki, Yuma, Yamaji, Masayuki, Oya, Kanako, Hikita, Yuki, Aoyama, Tomoki, Mabuchi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996836/
https://www.ncbi.nlm.nih.gov/pubmed/27605942
http://dx.doi.org/10.11909/j.issn.1671-5411.2016.07.014
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author Nishiguchi, Shu
Nozaki, Yuma
Yamaji, Masayuki
Oya, Kanako
Hikita, Yuki
Aoyama, Tomoki
Mabuchi, Hiroshi
author_facet Nishiguchi, Shu
Nozaki, Yuma
Yamaji, Masayuki
Oya, Kanako
Hikita, Yuki
Aoyama, Tomoki
Mabuchi, Hiroshi
author_sort Nishiguchi, Shu
collection PubMed
description OBJECTIVE: To determine the association between plasma brain natriuretic peptide (BNP) level in patients with heart failure (HF) and physical frailty as well as with each domain of physical frailty. METHODS: Two hundred and six outpatients of cardiovascular medicine aged 60 years and older who had been hospitalized for HF or had been given a prescription medication for HF were included. Physical frailty was assessed using the following five domains: slowness, weakness, exhaustion, low activity, and shrinking, according to the Cardiovascular Health Study. Patients were divided into nonfrailty and frailty groups according to frailty scores. Plasma BNP level was measured. The 6-min walk test was performed to measure endurance. RESULTS: Plasma BNP was significantly different between the two groups (frailty group: 158.0 ± 214.7 pg/mL, nonfrailty group: 65.2 ± 88.0 pg/mL, P < 0.01). Multivariate logistic regression analysis revealed log-transformed plasma BNP (Log BNP) was significantly associated with physical frailty (OR: 1.68, 95% CI: 1.11–2.56), and Log BNP was significantly associated with the slowness domain (walking speed < 1.0 m/s) of physical frailty (OR: 1.75, 95% CI: 1.15–2.67). Additionally, Log BNP was negatively correlated to the 6-minute walk distance (6MWD) (ρ = −0.37, P < 0.01), while 6MWD was positively correlated to walking speed (ρ = 0.66, P < 0.01). CONCLUSIONS: Plasma BNP level was related to physical frailty, especially in the slowness domain. Endurance may intervene in the associations between plasma BNP level and walking speed.
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spelling pubmed-49968362016-09-07 Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain Nishiguchi, Shu Nozaki, Yuma Yamaji, Masayuki Oya, Kanako Hikita, Yuki Aoyama, Tomoki Mabuchi, Hiroshi J Geriatr Cardiol Research Article OBJECTIVE: To determine the association between plasma brain natriuretic peptide (BNP) level in patients with heart failure (HF) and physical frailty as well as with each domain of physical frailty. METHODS: Two hundred and six outpatients of cardiovascular medicine aged 60 years and older who had been hospitalized for HF or had been given a prescription medication for HF were included. Physical frailty was assessed using the following five domains: slowness, weakness, exhaustion, low activity, and shrinking, according to the Cardiovascular Health Study. Patients were divided into nonfrailty and frailty groups according to frailty scores. Plasma BNP level was measured. The 6-min walk test was performed to measure endurance. RESULTS: Plasma BNP was significantly different between the two groups (frailty group: 158.0 ± 214.7 pg/mL, nonfrailty group: 65.2 ± 88.0 pg/mL, P < 0.01). Multivariate logistic regression analysis revealed log-transformed plasma BNP (Log BNP) was significantly associated with physical frailty (OR: 1.68, 95% CI: 1.11–2.56), and Log BNP was significantly associated with the slowness domain (walking speed < 1.0 m/s) of physical frailty (OR: 1.75, 95% CI: 1.15–2.67). Additionally, Log BNP was negatively correlated to the 6-minute walk distance (6MWD) (ρ = −0.37, P < 0.01), while 6MWD was positively correlated to walking speed (ρ = 0.66, P < 0.01). CONCLUSIONS: Plasma BNP level was related to physical frailty, especially in the slowness domain. Endurance may intervene in the associations between plasma BNP level and walking speed. Science Press 2016-07 /pmc/articles/PMC4996836/ /pubmed/27605942 http://dx.doi.org/10.11909/j.issn.1671-5411.2016.07.014 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Article
Nishiguchi, Shu
Nozaki, Yuma
Yamaji, Masayuki
Oya, Kanako
Hikita, Yuki
Aoyama, Tomoki
Mabuchi, Hiroshi
Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title_full Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title_fullStr Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title_full_unstemmed Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title_short Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
title_sort plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996836/
https://www.ncbi.nlm.nih.gov/pubmed/27605942
http://dx.doi.org/10.11909/j.issn.1671-5411.2016.07.014
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