Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by mel...

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Detalles Bibliográficos
Autores principales: Eskiocak, Ugur, Ramesh, Vijayashree, Gill, Jennifer G., Zhao, Zhiyu, Yuan, Stacy W., Wang, Meng, Vandergriff, Travis, Shackleton, Mark, Quintana, Elsa, Johnson, Timothy M., DeBerardinis, Ralph J., Morrison, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996948/
https://www.ncbi.nlm.nih.gov/pubmed/27545456
http://dx.doi.org/10.1038/ncomms12336

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