An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation

Chronic hepatitis B infection remains incurable because HBV cccDNA can persist indefinitely in patients recovering from acute HBV infection. Given the incidence of HBV infection and the shortcomings of current therapeutic options, a novel antiviral strategy is urgently needed. To inactivate HBV repl...

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Detalles Bibliográficos
Autores principales: Li, Hao, Sheng, Chunyu, Liu, Hongbo, Liu, Guangze, Du, Xinying, Du, Juan, Zhan, Linsheng, Li, Peng, Yang, Chaojie, Qi, Lihua, Wang, Jian, Yang, Xiaoxia, Jia, Leili, Xie, Jing, Wang, Ligui, Hao, Rongzhang, Xu, Dongping, Tong, Yigang, Zhou, Yusen, Zhou, Jianjun, Sun, Yansong, Li, Qiao, Qiu, Shaofu, Song, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997054/
https://www.ncbi.nlm.nih.gov/pubmed/27570484
http://dx.doi.org/10.7150/ijbs.16064

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