Cargando…
Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases
Mononuclear Ru(III) complexes of the type [Ru(LL)Cl(2)(H(2)O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME]...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997098/ https://www.ncbi.nlm.nih.gov/pubmed/27597814 http://dx.doi.org/10.1155/2016/9672451 |
_version_ | 1782449707514068992 |
---|---|
author | Ejidike, Ikechukwu P. Ajibade, Peter A. |
author_facet | Ejidike, Ikechukwu P. Ajibade, Peter A. |
author_sort | Ejidike, Ikechukwu P. |
collection | PubMed |
description | Mononuclear Ru(III) complexes of the type [Ru(LL)Cl(2)(H(2)O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl(2)(H(2)O)] showed the highest activity with IC(50) valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl(2)(H(2)O)] > [Ru(HME)Cl(2)(H(2)O)] > [Ru(DAE)Cl(2)(H(2)O)] > [Ru(MBE)Cl(2)(H(2)O)]. |
format | Online Article Text |
id | pubmed-4997098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-49970982016-09-05 Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases Ejidike, Ikechukwu P. Ajibade, Peter A. Bioinorg Chem Appl Research Article Mononuclear Ru(III) complexes of the type [Ru(LL)Cl(2)(H(2)O)] (LL = monobasic tridentate Schiff base anion: (1Z)-N′-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)-N-phenylethanimidamide [DAE], 4-[(1E)-N-{2-[(Z)-(4-hydroxy-3-methoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [HME], 4-[(1E)-N-{2-[(Z)-(3,4-dimethoxybenzylidene)amino]ethyl}ethanimidoyl]benzene-1,3-diol [MBE], and N-(2-{(E)-[1-(2,4-dihydroxyphenyl)ethylidene]amino}ethyl)benzenecarboximidoyl chloride [DEE]) were synthesized and characterized using the microanalytical, conductivity measurements, electronic spectra, and FTIR spectroscopy. IR spectral studies confirmed that the ligands act as tridentate chelate coordinating the metal ion through the azomethine nitrogen and phenolic oxygen atom. An octahedral geometry has been proposed for all Ru(III)-Schiff base complexes. In vitro anticancer studies of the synthesized complexes against renal cancer cells (TK-10), melanoma cancer cells (UACC-62), and breast cancer cells (MCF-7) was investigated using the Sulforhodamine B assay. [Ru(DAE)Cl(2)(H(2)O)] showed the highest activity with IC(50) valves of 3.57 ± 1.09, 6.44 ± 0.38, and 9.06 ± 1.18 μM against MCF-7, UACC-62, and TK-10, respectively, order of activity being TK-10 < UACC-62 < MCF-7. The antioxidant activity by DPPH and ABTS inhibition assay was also examined. Scavenging ability of the complexes on DPPH radical can be ranked in the following order: [Ru(DEE)Cl(2)(H(2)O)] > [Ru(HME)Cl(2)(H(2)O)] > [Ru(DAE)Cl(2)(H(2)O)] > [Ru(MBE)Cl(2)(H(2)O)]. Hindawi Publishing Corporation 2016 2016-08-11 /pmc/articles/PMC4997098/ /pubmed/27597814 http://dx.doi.org/10.1155/2016/9672451 Text en Copyright © 2016 I. P. Ejidike and P. A. Ajibade. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ejidike, Ikechukwu P. Ajibade, Peter A. Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title | Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title_full | Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title_fullStr | Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title_full_unstemmed | Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title_short | Synthesis, Characterization, Anticancer, and Antioxidant Studies of Ru(III) Complexes of Monobasic Tridentate Schiff Bases |
title_sort | synthesis, characterization, anticancer, and antioxidant studies of ru(iii) complexes of monobasic tridentate schiff bases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997098/ https://www.ncbi.nlm.nih.gov/pubmed/27597814 http://dx.doi.org/10.1155/2016/9672451 |
work_keys_str_mv | AT ejidikeikechukwup synthesischaracterizationanticancerandantioxidantstudiesofruiiicomplexesofmonobasictridentateschiffbases AT ajibadepetera synthesischaracterizationanticancerandantioxidantstudiesofruiiicomplexesofmonobasictridentateschiffbases |