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Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)

Background: To our knowledge the efficacy of soy-dairy protein blend (PB) supplementation with resistance exercise training (RET) has not been evaluated in a longitudinal study. Objective: Our aim was to determine the effect of PB supplementation during RET on muscle adaptation. Methods: In this dou...

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Autores principales: Reidy, Paul T, Borack, Michael S, Markofski, Melissa M, Dickinson, Jared M, Deer, Rachel R, Husaini, Syed H, Walker, Dillon K, Igbinigie, Sherry, Robertson, Shay M, Cope, Mark B, Mukherjea, Ratna, Hall-Porter, Janine M, Jennings, Kristofer, Volpi, Elena, Rasmussen, Blake B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Nutrition 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997282/
https://www.ncbi.nlm.nih.gov/pubmed/27466602
http://dx.doi.org/10.3945/jn.116.231803
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author Reidy, Paul T
Borack, Michael S
Markofski, Melissa M
Dickinson, Jared M
Deer, Rachel R
Husaini, Syed H
Walker, Dillon K
Igbinigie, Sherry
Robertson, Shay M
Cope, Mark B
Mukherjea, Ratna
Hall-Porter, Janine M
Jennings, Kristofer
Volpi, Elena
Rasmussen, Blake B
author_facet Reidy, Paul T
Borack, Michael S
Markofski, Melissa M
Dickinson, Jared M
Deer, Rachel R
Husaini, Syed H
Walker, Dillon K
Igbinigie, Sherry
Robertson, Shay M
Cope, Mark B
Mukherjea, Ratna
Hall-Porter, Janine M
Jennings, Kristofer
Volpi, Elena
Rasmussen, Blake B
author_sort Reidy, Paul T
collection PubMed
description Background: To our knowledge the efficacy of soy-dairy protein blend (PB) supplementation with resistance exercise training (RET) has not been evaluated in a longitudinal study. Objective: Our aim was to determine the effect of PB supplementation during RET on muscle adaptation. Methods: In this double-blind randomized clinical trial, healthy young men [18–30 y; BMI (in kg/m(2)): 25 ± 0.5] participated in supervised whole-body RET at 60–80% 1-repetition maximum (1-RM) for 3 d/wk for 12 wk with random assignment to daily receive 22 g PB (n = 23), whey protein (WP) isolate (n = 22), or an isocaloric maltodextrin (carbohydrate) placebo [(MDP) n = 23]. Serum testosterone, muscle strength, thigh muscle thickness (MT), myofiber cross-sectional area (mCSA), and lean body mass (LBM) were assessed before and after 6 and 12 wk of RET. Results: All treatments increased LBM (P < 0.001). ANCOVA did not identify an overall treatment effect at 12 wk (P = 0.11). There tended to be a greater change in LBM from baseline to 12 wk in the PB group than in the MDP group (0.92 kg; 95% CI: −0.12, 1.95 kg; P = 0.09); however, changes in the WP and MDP groups did not differ. Pooling data from combined PB and WP treatments showed a trend for greater change in LBM from baseline to 12 wk compared with MDP treatment (0.69 kg; 95% CI: −0.08, 1.46 kg; P = 0.08). Muscle strength, mCSA, and MT increased (P < 0.05) similarly for all treatments and were not different (P > 0.10) between treatments. Testosterone was not altered. Conclusions: PB supplementation during 3 mo of RET tended to slightly enhance gains in whole-body and arm LBM, but not leg muscle mass, compared with RET without protein supplementation. Although protein supplementation minimally enhanced gains in LBM of healthy young men, there was no enhancement of gains in strength. This trial was registered at clinicaltrials.gov as NCT01749189.
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spelling pubmed-49972822017-09-01 Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3) Reidy, Paul T Borack, Michael S Markofski, Melissa M Dickinson, Jared M Deer, Rachel R Husaini, Syed H Walker, Dillon K Igbinigie, Sherry Robertson, Shay M Cope, Mark B Mukherjea, Ratna Hall-Porter, Janine M Jennings, Kristofer Volpi, Elena Rasmussen, Blake B J Nutr Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions Background: To our knowledge the efficacy of soy-dairy protein blend (PB) supplementation with resistance exercise training (RET) has not been evaluated in a longitudinal study. Objective: Our aim was to determine the effect of PB supplementation during RET on muscle adaptation. Methods: In this double-blind randomized clinical trial, healthy young men [18–30 y; BMI (in kg/m(2)): 25 ± 0.5] participated in supervised whole-body RET at 60–80% 1-repetition maximum (1-RM) for 3 d/wk for 12 wk with random assignment to daily receive 22 g PB (n = 23), whey protein (WP) isolate (n = 22), or an isocaloric maltodextrin (carbohydrate) placebo [(MDP) n = 23]. Serum testosterone, muscle strength, thigh muscle thickness (MT), myofiber cross-sectional area (mCSA), and lean body mass (LBM) were assessed before and after 6 and 12 wk of RET. Results: All treatments increased LBM (P < 0.001). ANCOVA did not identify an overall treatment effect at 12 wk (P = 0.11). There tended to be a greater change in LBM from baseline to 12 wk in the PB group than in the MDP group (0.92 kg; 95% CI: −0.12, 1.95 kg; P = 0.09); however, changes in the WP and MDP groups did not differ. Pooling data from combined PB and WP treatments showed a trend for greater change in LBM from baseline to 12 wk compared with MDP treatment (0.69 kg; 95% CI: −0.08, 1.46 kg; P = 0.08). Muscle strength, mCSA, and MT increased (P < 0.05) similarly for all treatments and were not different (P > 0.10) between treatments. Testosterone was not altered. Conclusions: PB supplementation during 3 mo of RET tended to slightly enhance gains in whole-body and arm LBM, but not leg muscle mass, compared with RET without protein supplementation. Although protein supplementation minimally enhanced gains in LBM of healthy young men, there was no enhancement of gains in strength. This trial was registered at clinicaltrials.gov as NCT01749189. American Society for Nutrition 2016-09 2016-07-27 /pmc/articles/PMC4997282/ /pubmed/27466602 http://dx.doi.org/10.3945/jn.116.231803 Text en © 2016 American Society for Nutrition This is a free access article, distributed under terms (http://www.nutrition.org/publications/guidelines-and-policies/license/) that permit unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
Reidy, Paul T
Borack, Michael S
Markofski, Melissa M
Dickinson, Jared M
Deer, Rachel R
Husaini, Syed H
Walker, Dillon K
Igbinigie, Sherry
Robertson, Shay M
Cope, Mark B
Mukherjea, Ratna
Hall-Porter, Janine M
Jennings, Kristofer
Volpi, Elena
Rasmussen, Blake B
Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title_full Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title_fullStr Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title_full_unstemmed Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title_short Protein Supplementation Has Minimal Effects on Muscle Adaptations during Resistance Exercise Training in Young Men: A Double-Blind Randomized Clinical Trial(1)(2)(3)
title_sort protein supplementation has minimal effects on muscle adaptations during resistance exercise training in young men: a double-blind randomized clinical trial(1)(2)(3)
topic Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997282/
https://www.ncbi.nlm.nih.gov/pubmed/27466602
http://dx.doi.org/10.3945/jn.116.231803
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