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Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotic...

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Autores principales: Huang, Ruixue, Wang, Ke, Hu, Jianan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
https://www.ncbi.nlm.nih.gov/pubmed/27509521
http://dx.doi.org/10.3390/nu8080483
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author Huang, Ruixue
Wang, Ke
Hu, Jianan
author_facet Huang, Ruixue
Wang, Ke
Hu, Jianan
author_sort Huang, Ruixue
collection PubMed
description It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = −0.30, 95% CI (−0.51–−0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = −0.25, 95% CI (−0.47–−0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = −0.73, 95% CI (−1.37–−0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = −0.43, 95% CI (−0.72–−0.13), p = 0.005), while it had no effect on people aged over 65 (MD = −0.18, 95% CI (−0.47–0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression.
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spelling pubmed-49973962016-08-26 Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Huang, Ruixue Wang, Ke Hu, Jianan Nutrients Review It has been reported that gut probiotics play a major role in the bidirectional communication between the gut and the brain. Probiotics may be essential to people with depression, which remains a global health challenge, as depression is a metabolic brain disorder. However, the efficacy of probiotics for depression is controversial. This study aimed to systematically review the existing evidence on the effect of probiotics-based interventions on depression. Randomized, controlled trials, identified through screening multiple databases and grey literature, were included in the meta-analysis. The meta-analysis was performed using Review Manager 5.3 software using a fixed-effects model. The meta-analysis showed that probiotics significantly decreased the depression scale score (MD (depressive disorder) = −0.30, 95% CI (−0.51–−0.09), p = 0.005) in the subjects. Probiotics had an effect on both the healthy population (MD = −0.25, 95% CI (−0.47–−0.03), p = 0.03) and patients with major depressive disorder (MDD) (MD = −0.73, 95% CI (−1.37–−0.09), p = 0.03). Probiotics had an effect on the population aged under 60 (MD = −0.43, 95% CI (−0.72–−0.13), p = 0.005), while it had no effect on people aged over 65 (MD = −0.18, 95% CI (−0.47–0.11), p = 0.22). This is the first systematic review and meta-analysis with the goal of determining the effect of probiotics on depression. We found that probiotics were associated with a significant reduction in depression, underscoring the need for additional research on this potential preventive strategy for depression. MDPI 2016-08-06 /pmc/articles/PMC4997396/ /pubmed/27509521 http://dx.doi.org/10.3390/nu8080483 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Huang, Ruixue
Wang, Ke
Hu, Jianan
Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997396/
https://www.ncbi.nlm.nih.gov/pubmed/27509521
http://dx.doi.org/10.3390/nu8080483
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