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Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study
Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO(2)) and sulphur dioxide (SO(2...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997486/ https://www.ncbi.nlm.nih.gov/pubmed/27517941 http://dx.doi.org/10.3390/ijerph13080800 |
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author | Anyenda, Enoch Olando Higashi, Tomomi Kambayashi, Yasuhiro Nguyen, Thao Thi Thu Michigami, Yoshimasa Fujimura, Masaki Hara, Johsuke Tsujiguchi, Hiromasa Kitaoka, Masami Asakura, Hiroki Hori, Daisuke Yamada, Yohei Hayashi, Koichiro Hayakawa, Kazuichi Nakamura, Hiroyuki |
author_facet | Anyenda, Enoch Olando Higashi, Tomomi Kambayashi, Yasuhiro Nguyen, Thao Thi Thu Michigami, Yoshimasa Fujimura, Masaki Hara, Johsuke Tsujiguchi, Hiromasa Kitaoka, Masami Asakura, Hiroki Hori, Daisuke Yamada, Yohei Hayashi, Koichiro Hayakawa, Kazuichi Nakamura, Hiroyuki |
author_sort | Anyenda, Enoch Olando |
collection | PubMed |
description | Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO(2)) and sulphur dioxide (SO(2)) exposures with cough prevalence. Eighty-three adult patients, who had been physician diagnosed with at least asthma, cough variant asthma and/or atopic cough, were divided into asthma and non-asthma groups. They recorded daily cough symptoms during 4 January–30 June 2011 study period while daily samples of total suspended particles were simultaneously collected by use of glass fiber filters and the particulate PAH content determined by high performance liquid chromatography coupled with a fluorescence detector. Ambient concentrations of NO(2) and SO(2) were obtained from a local monitoring site. Logistic regression models using generalized estimating equations were used to determine population-averaged estimates of association between cough prevalence and ambient pollutant exposures for the two groups. Fully adjusted odds ratios from single pollutant models were 1.083 (95% confidence interval (CI): 1.029, 1.140) and 1.097 (95% CI: 1.016, 1.185) per 0.57 ng/m(3) for lag2 PAH exposure, while only for asthma group had significant associations with NO(2) and SO(2) exposures for both lag2 and lag02. Similar associations were observed in multipollutant models. This finding suggests that ambient PAH, NO(2), and SO(2) exposure even at low levels is related to cough prevalence in adult chronic cough patients and may be considered as aggravating factor during clinical management of the condition. |
format | Online Article Text |
id | pubmed-4997486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49974862016-08-26 Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study Anyenda, Enoch Olando Higashi, Tomomi Kambayashi, Yasuhiro Nguyen, Thao Thi Thu Michigami, Yoshimasa Fujimura, Masaki Hara, Johsuke Tsujiguchi, Hiromasa Kitaoka, Masami Asakura, Hiroki Hori, Daisuke Yamada, Yohei Hayashi, Koichiro Hayakawa, Kazuichi Nakamura, Hiroyuki Int J Environ Res Public Health Article Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO(2)) and sulphur dioxide (SO(2)) exposures with cough prevalence. Eighty-three adult patients, who had been physician diagnosed with at least asthma, cough variant asthma and/or atopic cough, were divided into asthma and non-asthma groups. They recorded daily cough symptoms during 4 January–30 June 2011 study period while daily samples of total suspended particles were simultaneously collected by use of glass fiber filters and the particulate PAH content determined by high performance liquid chromatography coupled with a fluorescence detector. Ambient concentrations of NO(2) and SO(2) were obtained from a local monitoring site. Logistic regression models using generalized estimating equations were used to determine population-averaged estimates of association between cough prevalence and ambient pollutant exposures for the two groups. Fully adjusted odds ratios from single pollutant models were 1.083 (95% confidence interval (CI): 1.029, 1.140) and 1.097 (95% CI: 1.016, 1.185) per 0.57 ng/m(3) for lag2 PAH exposure, while only for asthma group had significant associations with NO(2) and SO(2) exposures for both lag2 and lag02. Similar associations were observed in multipollutant models. This finding suggests that ambient PAH, NO(2), and SO(2) exposure even at low levels is related to cough prevalence in adult chronic cough patients and may be considered as aggravating factor during clinical management of the condition. MDPI 2016-08-09 2016-08 /pmc/articles/PMC4997486/ /pubmed/27517941 http://dx.doi.org/10.3390/ijerph13080800 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Anyenda, Enoch Olando Higashi, Tomomi Kambayashi, Yasuhiro Nguyen, Thao Thi Thu Michigami, Yoshimasa Fujimura, Masaki Hara, Johsuke Tsujiguchi, Hiromasa Kitaoka, Masami Asakura, Hiroki Hori, Daisuke Yamada, Yohei Hayashi, Koichiro Hayakawa, Kazuichi Nakamura, Hiroyuki Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title | Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title_full | Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title_fullStr | Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title_full_unstemmed | Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title_short | Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study |
title_sort | associations of cough prevalence with ambient polycyclic aromatic hydrocarbons, nitrogen and sulphur dioxide: a longitudinal study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997486/ https://www.ncbi.nlm.nih.gov/pubmed/27517941 http://dx.doi.org/10.3390/ijerph13080800 |
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