Cargando…
A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy
Aims: To shed light on the conflicting findings of the association between the methylenetetrahydrofolate reductase gene (MTHFR) 677C/T polymorphism and the risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods: A predefined search was performed on 1747 DR cases and 3146 controls...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997492/ https://www.ncbi.nlm.nih.gov/pubmed/27517946 http://dx.doi.org/10.3390/ijerph13080806 |
_version_ | 1782449787868545024 |
---|---|
author | Luo, Shasha Wang, Furu Shi, Chao Wu, Zhifeng |
author_facet | Luo, Shasha Wang, Furu Shi, Chao Wu, Zhifeng |
author_sort | Luo, Shasha |
collection | PubMed |
description | Aims: To shed light on the conflicting findings of the association between the methylenetetrahydrofolate reductase gene (MTHFR) 677C/T polymorphism and the risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods: A predefined search was performed on 1747 DR cases and 3146 controls from 18 published studies by searching electronic databases and reference lists of relevant articles. A random-effects or fixed-effects model was used to estimate the sizes of overall and stratification effects of the MTHFR 677C/T polymorphism on the risk of DR, as appropriate. Results: Risks were evaluated by odds ratios (OR) with 95% confidence intervals (95% CI). We found a significant association between the MTHFR 677C/T polymorphism and the risk of DR for each genetic model (recessive model: OR = 1.67; 95% CI: 1.19–2.40 and dominant model: OR = 1.71; 95% CI: 1.28–2.28; respectively). In stratified analysis; we further found that the Asian group with both types of diabetes mellitus (DM) showed a significant association with genetic models (recessive model: OR = 2.16; 95% CI: 1.75–2.60 and dominant model: OR = 1.98; 95% CI: 1.42–2.76; respectively). Conclusions: Our study suggested that the MTHFR 677C/T polymorphism may contribute to DR development, especially in Asian populations. Prospective and additional genome-wide association studies (GWAS) are needed to clarify the real role of the MTHFR gene in determining susceptibility to DR. |
format | Online Article Text |
id | pubmed-4997492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49974922016-08-26 A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy Luo, Shasha Wang, Furu Shi, Chao Wu, Zhifeng Int J Environ Res Public Health Article Aims: To shed light on the conflicting findings of the association between the methylenetetrahydrofolate reductase gene (MTHFR) 677C/T polymorphism and the risk of diabetic retinopathy (DR), a meta-analysis was conducted. Methods: A predefined search was performed on 1747 DR cases and 3146 controls from 18 published studies by searching electronic databases and reference lists of relevant articles. A random-effects or fixed-effects model was used to estimate the sizes of overall and stratification effects of the MTHFR 677C/T polymorphism on the risk of DR, as appropriate. Results: Risks were evaluated by odds ratios (OR) with 95% confidence intervals (95% CI). We found a significant association between the MTHFR 677C/T polymorphism and the risk of DR for each genetic model (recessive model: OR = 1.67; 95% CI: 1.19–2.40 and dominant model: OR = 1.71; 95% CI: 1.28–2.28; respectively). In stratified analysis; we further found that the Asian group with both types of diabetes mellitus (DM) showed a significant association with genetic models (recessive model: OR = 2.16; 95% CI: 1.75–2.60 and dominant model: OR = 1.98; 95% CI: 1.42–2.76; respectively). Conclusions: Our study suggested that the MTHFR 677C/T polymorphism may contribute to DR development, especially in Asian populations. Prospective and additional genome-wide association studies (GWAS) are needed to clarify the real role of the MTHFR gene in determining susceptibility to DR. MDPI 2016-08-10 2016-08 /pmc/articles/PMC4997492/ /pubmed/27517946 http://dx.doi.org/10.3390/ijerph13080806 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Luo, Shasha Wang, Furu Shi, Chao Wu, Zhifeng A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title | A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title_full | A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title_fullStr | A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title_full_unstemmed | A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title_short | A Meta-Analysis of Association between Methylenetetrahydrofolate Reductase Gene (MTHFR) 677C/T Polymorphism and Diabetic Retinopathy |
title_sort | meta-analysis of association between methylenetetrahydrofolate reductase gene (mthfr) 677c/t polymorphism and diabetic retinopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997492/ https://www.ncbi.nlm.nih.gov/pubmed/27517946 http://dx.doi.org/10.3390/ijerph13080806 |
work_keys_str_mv | AT luoshasha ametaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT wangfuru ametaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT shichao ametaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT wuzhifeng ametaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT luoshasha metaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT wangfuru metaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT shichao metaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy AT wuzhifeng metaanalysisofassociationbetweenmethylenetetrahydrofolatereductasegenemthfr677ctpolymorphismanddiabeticretinopathy |