Role of Envelopment in the HEV Life Cycle

Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient’s blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery...

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Detalles Bibliográficos
Autores principales: Yin, Xin, Li, Xinlei, Feng, Zongdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997591/
https://www.ncbi.nlm.nih.gov/pubmed/27548201
http://dx.doi.org/10.3390/v8080229
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author Yin, Xin
Li, Xinlei
Feng, Zongdi
author_facet Yin, Xin
Li, Xinlei
Feng, Zongdi
author_sort Yin, Xin
collection PubMed
description Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient’s blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity.
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spelling pubmed-49975912016-08-26 Role of Envelopment in the HEV Life Cycle Yin, Xin Li, Xinlei Feng, Zongdi Viruses Review Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-enveloped for decades. However, recent studies have revealed that the virus circulating in the patient’s blood is completely cloaked in host membranes and resistant to neutralizing antibodies. The discovery of this novel enveloped form of HEV has raised a series of questions about the fundamental biology of HEV and the way this virus, which has been understudied in the past, interacts with its host. Here, we review recent advances towards understanding this phenomenon and discuss its potential impact on various aspects of the HEV life cycle and immunity. MDPI 2016-08-18 /pmc/articles/PMC4997591/ /pubmed/27548201 http://dx.doi.org/10.3390/v8080229 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yin, Xin
Li, Xinlei
Feng, Zongdi
Role of Envelopment in the HEV Life Cycle
title Role of Envelopment in the HEV Life Cycle
title_full Role of Envelopment in the HEV Life Cycle
title_fullStr Role of Envelopment in the HEV Life Cycle
title_full_unstemmed Role of Envelopment in the HEV Life Cycle
title_short Role of Envelopment in the HEV Life Cycle
title_sort role of envelopment in the hev life cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997591/
https://www.ncbi.nlm.nih.gov/pubmed/27548201
http://dx.doi.org/10.3390/v8080229
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AT lixinlei roleofenvelopmentinthehevlifecycle
AT fengzongdi roleofenvelopmentinthehevlifecycle

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