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Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review

The aim of this systematic review was to identify, assess and summarize studies about potentially inappropriate drug use (IDU) in cognitive impairment and dementia and to present findings about whether cognitive impairment and dementia are associated with IDU. The search was made in Medline/PubMed u...

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Autor principal: Johnell, Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997919/
https://www.ncbi.nlm.nih.gov/pubmed/26054404
http://dx.doi.org/10.2174/1574884710666150609154741
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author Johnell, Kristina
author_facet Johnell, Kristina
author_sort Johnell, Kristina
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description The aim of this systematic review was to identify, assess and summarize studies about potentially inappropriate drug use (IDU) in cognitive impairment and dementia and to present findings about whether cognitive impairment and dementia are associated with IDU. The search was made in Medline/PubMed using free terms in the title or abstract. The inclusion criteria were: English language, published until 1 March 2014, original quantitative study and assessment of overall IDU with a consensus based summarized measure. Exclusion criteria were: focus on specific patient group (other than cognitive impairment or dementia), focus on specific drug class and failure to present a prevalence measure of IDU or an effect estimate (i.e. odds ratio). Of the initial 182 studies found in Medline, 22 articles fulfilled the criteria. Most studies used the Beers criteria for assessment of IDU. Prevalence of IDU among individuals with cognitive impairment or dementia ranged from 10.2% to 56.4% and was higher in nursing home settings than in community-dwelling samples. Most studies reported a lower likelihood of IDU in case of cognitive impairment or dementia. To conclude, IDU is highly prevalent among persons with cognitive impairment and dementia, although these conditions seem to be associated with a lower probability of IDU. This might reflect an awareness among clinicians of cautious prescribing to this vulnerable group of patients. More studies on large cohorts of persons with cognitive impairment and dementia are needed to draw conclusions about optimal drug prescribing to this frail group of older persons.
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spelling pubmed-49979192016-08-31 Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review Johnell, Kristina Curr Clin Pharmacol Article The aim of this systematic review was to identify, assess and summarize studies about potentially inappropriate drug use (IDU) in cognitive impairment and dementia and to present findings about whether cognitive impairment and dementia are associated with IDU. The search was made in Medline/PubMed using free terms in the title or abstract. The inclusion criteria were: English language, published until 1 March 2014, original quantitative study and assessment of overall IDU with a consensus based summarized measure. Exclusion criteria were: focus on specific patient group (other than cognitive impairment or dementia), focus on specific drug class and failure to present a prevalence measure of IDU or an effect estimate (i.e. odds ratio). Of the initial 182 studies found in Medline, 22 articles fulfilled the criteria. Most studies used the Beers criteria for assessment of IDU. Prevalence of IDU among individuals with cognitive impairment or dementia ranged from 10.2% to 56.4% and was higher in nursing home settings than in community-dwelling samples. Most studies reported a lower likelihood of IDU in case of cognitive impairment or dementia. To conclude, IDU is highly prevalent among persons with cognitive impairment and dementia, although these conditions seem to be associated with a lower probability of IDU. This might reflect an awareness among clinicians of cautious prescribing to this vulnerable group of patients. More studies on large cohorts of persons with cognitive impairment and dementia are needed to draw conclusions about optimal drug prescribing to this frail group of older persons. Bentham Science Publishers 2015-08 2015-08 /pmc/articles/PMC4997919/ /pubmed/26054404 http://dx.doi.org/10.2174/1574884710666150609154741 Text en © 2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode ), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Johnell, Kristina
Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title_full Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title_fullStr Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title_full_unstemmed Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title_short Inappropriate Drug Use in People with Cognitive Impairment and Dementia: A Systematic Review
title_sort inappropriate drug use in people with cognitive impairment and dementia: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997919/
https://www.ncbi.nlm.nih.gov/pubmed/26054404
http://dx.doi.org/10.2174/1574884710666150609154741
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