The Use of Anthracyclines for Therapy of CNS Tumors

Despite being long lived, anthracyclines remain the “evergreen” drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administe...

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Detalles Bibliográficos
Autores principales: da Ros, Martina, Iorio, Anna Lisa, Lucchesi, Maurizio, Stival, Alessia, de Martino, Maurizio, Sardi, Iacopo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997942/
https://www.ncbi.nlm.nih.gov/pubmed/25846760
http://dx.doi.org/10.2174/1871520615666150407155319
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author da Ros, Martina
Iorio, Anna Lisa
Lucchesi, Maurizio
Stival, Alessia
de Martino, Maurizio
Sardi, Iacopo
author_facet da Ros, Martina
Iorio, Anna Lisa
Lucchesi, Maurizio
Stival, Alessia
de Martino, Maurizio
Sardi, Iacopo
author_sort da Ros, Martina
collection PubMed
description Despite being long lived, anthracyclines remain the “evergreen” drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidrug resistance mechanism, which hampers their delivery across the blood brain barrier. In this paper, we summarize the current literature on the role of anthracyclines in cancer therapy and highlight recent efforts on 1) development of tumor cell resistance to anthracyclines and 2) the new approaches to brain drug delivery across the blood brain barrier.
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spelling pubmed-49979422016-08-31 The Use of Anthracyclines for Therapy of CNS Tumors da Ros, Martina Iorio, Anna Lisa Lucchesi, Maurizio Stival, Alessia de Martino, Maurizio Sardi, Iacopo Anticancer Agents Med Chem Article Despite being long lived, anthracyclines remain the “evergreen” drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidrug resistance mechanism, which hampers their delivery across the blood brain barrier. In this paper, we summarize the current literature on the role of anthracyclines in cancer therapy and highlight recent efforts on 1) development of tumor cell resistance to anthracyclines and 2) the new approaches to brain drug delivery across the blood brain barrier. Bentham Science Publishers 2015-06 2015-06 /pmc/articles/PMC4997942/ /pubmed/25846760 http://dx.doi.org/10.2174/1871520615666150407155319 Text en © 2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode ), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
da Ros, Martina
Iorio, Anna Lisa
Lucchesi, Maurizio
Stival, Alessia
de Martino, Maurizio
Sardi, Iacopo
The Use of Anthracyclines for Therapy of CNS Tumors
title The Use of Anthracyclines for Therapy of CNS Tumors
title_full The Use of Anthracyclines for Therapy of CNS Tumors
title_fullStr The Use of Anthracyclines for Therapy of CNS Tumors
title_full_unstemmed The Use of Anthracyclines for Therapy of CNS Tumors
title_short The Use of Anthracyclines for Therapy of CNS Tumors
title_sort use of anthracyclines for therapy of cns tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997942/
https://www.ncbi.nlm.nih.gov/pubmed/25846760
http://dx.doi.org/10.2174/1871520615666150407155319
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