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Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy
Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997955/ https://www.ncbi.nlm.nih.gov/pubmed/26031306 http://dx.doi.org/10.2174/1389203716666150515125002 |
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author | Macêdo, Jéssica Kele Arruda Fox, Jay W. Castro, Mariana de Souza |
author_facet | Macêdo, Jéssica Kele Arruda Fox, Jay W. Castro, Mariana de Souza |
author_sort | Macêdo, Jéssica Kele Arruda |
collection | PubMed |
description | Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability. |
format | Online Article Text |
id | pubmed-4997955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-49979552016-08-31 Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy Macêdo, Jéssica Kele Arruda Fox, Jay W. Castro, Mariana de Souza Curr Protein Pept Sci Article Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms of novel therapeutic leads for cancer treatment. Disintegrin can target specific integrins and as such it is conceivable that they could interfere in important processes involved in carcinogenesis, tumor growth, invasion and migration. Herein we present a survey of studies involving the use of snake venom disintegrins for cancer detection and treatment. The aim of this review is to highlight the relationship of integrins with cancer and to present examples as to how certain disintegrins can detect and affect biological processes related to cancer. This in turn will illustrate the great potential of these molecules for cancer research. Furthermore, we also outline several new approaches being created to address problems commonly associated with the clinical application of peptide-based drugs such as instability, immunogenicity, and availability. Bentham Science Publishers 2015-09 2015-09 /pmc/articles/PMC4997955/ /pubmed/26031306 http://dx.doi.org/10.2174/1389203716666150515125002 Text en © 2015 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/legalcode ), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Macêdo, Jéssica Kele Arruda Fox, Jay W. Castro, Mariana de Souza Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy |
title | Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy |
title_full | Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy |
title_fullStr | Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy |
title_full_unstemmed | Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy |
title_short | Disintegrins from Snake Venoms and their Applications in Cancer
Research and Therapy |
title_sort | disintegrins from snake venoms and their applications in cancer
research and therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997955/ https://www.ncbi.nlm.nih.gov/pubmed/26031306 http://dx.doi.org/10.2174/1389203716666150515125002 |
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