aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization

Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex component. It is recruited by Par3/Baz (Bazooka in Drosophila) into epithelial apical domains through high-affinity interaction. Paradoxically, aPKC also phosphorylates Par3/Baz, provoking its relocalization...

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Detalles Bibliográficos
Autores principales: Soriano, Erika V., Ivanova, Marina E., Fletcher, Georgina, Riou, Philippe, Knowles, Philip P., Barnouin, Karin, Purkiss, Andrew, Kostelecky, Brenda, Saiu, Peter, Linch, Mark, Elbediwy, Ahmed, Kjær, Svend, O’Reilly, Nicola, Snijders, Ambrosius P., Parker, Peter J., Thompson, Barry J., McDonald, Neil Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998004/
https://www.ncbi.nlm.nih.gov/pubmed/27554858
http://dx.doi.org/10.1016/j.devcel.2016.07.018

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