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Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms

Magnetic resonance imaging (MRI) with diffusion-tensor imaging (DTI) together with a white matter fiber tracking (FT) technique was used to assess different brain white matter structures and functionalities in schizophrenic patients with typical first negative symptoms. In total, 30 schizophrenic pa...

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Autores principales: Gu, Chengyu, Zhang, Ying, Wei, Fuquan, Cheng, Yougen, Cao, Yulin, Hou, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998077/
https://www.ncbi.nlm.nih.gov/pubmed/27588066
http://dx.doi.org/10.3892/etm.2016.3469
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author Gu, Chengyu
Zhang, Ying
Wei, Fuquan
Cheng, Yougen
Cao, Yulin
Hou, Hongtao
author_facet Gu, Chengyu
Zhang, Ying
Wei, Fuquan
Cheng, Yougen
Cao, Yulin
Hou, Hongtao
author_sort Gu, Chengyu
collection PubMed
description Magnetic resonance imaging (MRI) with diffusion-tensor imaging (DTI) together with a white matter fiber tracking (FT) technique was used to assess different brain white matter structures and functionalities in schizophrenic patients with typical first negative symptoms. In total, 30 schizophrenic patients with typical first negative symptoms, comprising an observation group were paired 1:1 according to gender, age, right-handedness, and education, with 30 healthy individuals in a control group. Individuals in each group underwent routine MRI and DTI examination of the brain, and diffusion-tensor tractography (DTT) data were obtained through whole brain analysis based on voxel and tractography. The results were expressed by fractional anisotropy (FA) values. The schizophrenic patients were evaluated using a positive and negative symptom scale (PANSS) as well as a Global Assessment Scale (GAS). The results of the study showed that routine MRIs identified no differences between the two groups. However, compared with the control group, the FA values obtained by DTT from the deep left prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum were significantly lower in the observation group (P<0.05). The PANSS positive scale value in the observation group averaged 7.7±1.5, and the negative scale averaged 46.6±5.9, while the general psychopathology scale averaged 65.4±10.3, and GAS averaged 53.8±19.2. The Pearson statistical analysis, the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and the FA value of part of the corpus callosum in the observation group was negatively correlated with the negative scale (P<0.05), and positively correlated with GAS (P<0.05). In conclusion, a decrease in the FA values of the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum may be associated with schizophrenia with typical first negative symptoms and the application of MRI DTI-FT can improve diagnostic accuracy.
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spelling pubmed-49980772016-09-01 Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms Gu, Chengyu Zhang, Ying Wei, Fuquan Cheng, Yougen Cao, Yulin Hou, Hongtao Exp Ther Med Articles Magnetic resonance imaging (MRI) with diffusion-tensor imaging (DTI) together with a white matter fiber tracking (FT) technique was used to assess different brain white matter structures and functionalities in schizophrenic patients with typical first negative symptoms. In total, 30 schizophrenic patients with typical first negative symptoms, comprising an observation group were paired 1:1 according to gender, age, right-handedness, and education, with 30 healthy individuals in a control group. Individuals in each group underwent routine MRI and DTI examination of the brain, and diffusion-tensor tractography (DTT) data were obtained through whole brain analysis based on voxel and tractography. The results were expressed by fractional anisotropy (FA) values. The schizophrenic patients were evaluated using a positive and negative symptom scale (PANSS) as well as a Global Assessment Scale (GAS). The results of the study showed that routine MRIs identified no differences between the two groups. However, compared with the control group, the FA values obtained by DTT from the deep left prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum were significantly lower in the observation group (P<0.05). The PANSS positive scale value in the observation group averaged 7.7±1.5, and the negative scale averaged 46.6±5.9, while the general psychopathology scale averaged 65.4±10.3, and GAS averaged 53.8±19.2. The Pearson statistical analysis, the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and the FA value of part of the corpus callosum in the observation group was negatively correlated with the negative scale (P<0.05), and positively correlated with GAS (P<0.05). In conclusion, a decrease in the FA values of the left deep prefrontal cortex, the right deep temporal lobe, the white matter of the inferior frontal gyrus and part of the corpus callosum may be associated with schizophrenia with typical first negative symptoms and the application of MRI DTI-FT can improve diagnostic accuracy. D.A. Spandidos 2016-09 2016-06-17 /pmc/articles/PMC4998077/ /pubmed/27588066 http://dx.doi.org/10.3892/etm.2016.3469 Text en Copyright: © Gu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Gu, Chengyu
Zhang, Ying
Wei, Fuquan
Cheng, Yougen
Cao, Yulin
Hou, Hongtao
Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title_full Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title_fullStr Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title_full_unstemmed Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title_short Magnetic resonance imaging DTI-FT study on schizophrenic patients with typical negative first symptoms
title_sort magnetic resonance imaging dti-ft study on schizophrenic patients with typical negative first symptoms
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998077/
https://www.ncbi.nlm.nih.gov/pubmed/27588066
http://dx.doi.org/10.3892/etm.2016.3469
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