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Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study
The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC). We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression a...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998244/ https://www.ncbi.nlm.nih.gov/pubmed/26817870 http://dx.doi.org/10.1097/MD.0000000000002407 |
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author | Tsai, Chia-Ta Ho, Mao-Wang Lin, Dana Chen, Hsuan-Ju Muo, Chih-Hsin Tseng, Chun-Hung Su, Wen-Chi Lin, Ming-Chia Kao, Chia-Hung |
author_facet | Tsai, Chia-Ta Ho, Mao-Wang Lin, Dana Chen, Hsuan-Ju Muo, Chih-Hsin Tseng, Chun-Hung Su, Wen-Chi Lin, Ming-Chia Kao, Chia-Hung |
author_sort | Tsai, Chia-Ta |
collection | PubMed |
description | The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC). We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort. A total of 99 patients in the COM and 228 patients in the comparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17–1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively). This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities. |
format | Online Article Text |
id | pubmed-4998244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49982442016-09-02 Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study Tsai, Chia-Ta Ho, Mao-Wang Lin, Dana Chen, Hsuan-Ju Muo, Chih-Hsin Tseng, Chun-Hung Su, Wen-Chi Lin, Ming-Chia Kao, Chia-Hung Medicine (Baltimore) 4900 The aim of study is to determine whether chronic osteomyelitis (COM) is linked to an increased risk of head and neck cancer (HNC). We identify 17,033 patients with osteomyelitis and 68,125 subjects without osteomyelitis during 1996 to 2010 periods. Multivariable Cox proportional hazards regression analysis was used to measure the hazard ratio (HR) of head and neck cancer for the osteomyelitis cohort compared with the comparison cohort. A total of 99 patients in the COM and 228 patients in the comparison cohort developed HNC during an average 5.12 years of follow-up period. The incidence rate of HNC in the COM cohort was 1.51-fold (95% confidence interval [CI]: 1.17–1.95) higher than that in the comparison cohort after adjusting gender, age, urbanization level, monthly income, and comorbidities. In subgroup analysis, younger (less than 45 years-old) and patients without comorbidities have greater risks (adjusted HR: 2.29 [95% CI:1.43-3.66] and 1.74 [95% CI:1.28-2.38] respectively). This study results suggested the association between COM and HNC, particularly in younger population and patients without comorbidities. Wolters Kluwer Health 2016-01-22 /pmc/articles/PMC4998244/ /pubmed/26817870 http://dx.doi.org/10.1097/MD.0000000000002407 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 4900 Tsai, Chia-Ta Ho, Mao-Wang Lin, Dana Chen, Hsuan-Ju Muo, Chih-Hsin Tseng, Chun-Hung Su, Wen-Chi Lin, Ming-Chia Kao, Chia-Hung Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title | Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title_full | Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title_fullStr | Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title_full_unstemmed | Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title_short | Association of Head and Neck Cancers in Chronic Osteomyelitis: A National Retrospective Cohort Study |
title_sort | association of head and neck cancers in chronic osteomyelitis: a national retrospective cohort study |
topic | 4900 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998244/ https://www.ncbi.nlm.nih.gov/pubmed/26817870 http://dx.doi.org/10.1097/MD.0000000000002407 |
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