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Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study

Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, the association between CO poisoning and long-term dementia risk remains unestablished. We investigated the incidence of dementia in patients with CO poisoning in Taiwan and evaluated whether they had...

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Autores principales: Wong, Chung-Shun, Lin, Ying-Chin, Hong, Li-Yee, Chen, Tzu-Ting, Ma, Hon-Ping, Hsu, Yung-Ho, Tsai, Shin-Han, Lin, Yuh-Feng, Wu, Mei-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998278/
https://www.ncbi.nlm.nih.gov/pubmed/26817904
http://dx.doi.org/10.1097/MD.0000000000002549
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author Wong, Chung-Shun
Lin, Ying-Chin
Hong, Li-Yee
Chen, Tzu-Ting
Ma, Hon-Ping
Hsu, Yung-Ho
Tsai, Shin-Han
Lin, Yuh-Feng
Wu, Mei-Yi
author_facet Wong, Chung-Shun
Lin, Ying-Chin
Hong, Li-Yee
Chen, Tzu-Ting
Ma, Hon-Ping
Hsu, Yung-Ho
Tsai, Shin-Han
Lin, Yuh-Feng
Wu, Mei-Yi
author_sort Wong, Chung-Shun
collection PubMed
description Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, the association between CO poisoning and long-term dementia risk remains unestablished. We investigated the incidence of dementia in patients with CO poisoning in Taiwan and evaluated whether they had a higher risk of dementia than did the general population. A nationwide population-based cohort study was conducted among patients with CO poisoning identified using Taiwan's National Health Insurance Research Database (NHIRD) during 2004 to 2013. CO poisoning was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The study cohort comprised patients with CO poisoning between 2005 and 2010 (N = 14,590). Each patient was age-, sex-, and index date-matched with 4 randomly selected controls from the comparison cohort (N = 58,360). All patients were followed from the study date until dementia development, death, or the end of 2013. Cox proportional hazards regressions were performed for comparing the hazard ratios for dementia between the 2 cohorts. Incident cases of dementia were identified from the NHIRD. After adjustment for potential confounders, the study cohort was independently associated with a higher dementia risk (adjusted hazard ratio, 2.75; 95% confidence interval, 2.26–3.35). This population-based cohort study indicated that patients with CO poisoning have a higher risk of dementia than do people without CO poisoning.
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spelling pubmed-49982782016-09-02 Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study Wong, Chung-Shun Lin, Ying-Chin Hong, Li-Yee Chen, Tzu-Ting Ma, Hon-Ping Hsu, Yung-Ho Tsai, Shin-Han Lin, Yuh-Feng Wu, Mei-Yi Medicine (Baltimore) 7200 Carbon monoxide (CO) poisoning may cause toxicity of the central nervous system and heart. However, the association between CO poisoning and long-term dementia risk remains unestablished. We investigated the incidence of dementia in patients with CO poisoning in Taiwan and evaluated whether they had a higher risk of dementia than did the general population. A nationwide population-based cohort study was conducted among patients with CO poisoning identified using Taiwan's National Health Insurance Research Database (NHIRD) during 2004 to 2013. CO poisoning was defined according to the International Classification of Diseases, Ninth Revision, Clinical Modification codes. The study cohort comprised patients with CO poisoning between 2005 and 2010 (N = 14,590). Each patient was age-, sex-, and index date-matched with 4 randomly selected controls from the comparison cohort (N = 58,360). All patients were followed from the study date until dementia development, death, or the end of 2013. Cox proportional hazards regressions were performed for comparing the hazard ratios for dementia between the 2 cohorts. Incident cases of dementia were identified from the NHIRD. After adjustment for potential confounders, the study cohort was independently associated with a higher dementia risk (adjusted hazard ratio, 2.75; 95% confidence interval, 2.26–3.35). This population-based cohort study indicated that patients with CO poisoning have a higher risk of dementia than do people without CO poisoning. Wolters Kluwer Health 2016-01-22 /pmc/articles/PMC4998278/ /pubmed/26817904 http://dx.doi.org/10.1097/MD.0000000000002549 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 7200
Wong, Chung-Shun
Lin, Ying-Chin
Hong, Li-Yee
Chen, Tzu-Ting
Ma, Hon-Ping
Hsu, Yung-Ho
Tsai, Shin-Han
Lin, Yuh-Feng
Wu, Mei-Yi
Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title_full Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title_fullStr Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title_full_unstemmed Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title_short Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study
title_sort increased long-term risk of dementia in patients with carbon monoxide poisoning: a population-based study
topic 7200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998278/
https://www.ncbi.nlm.nih.gov/pubmed/26817904
http://dx.doi.org/10.1097/MD.0000000000002549
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