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Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children

Despite treatment with combination antiretroviral therapy (cART), cognitive impairment is still observed in perinatally HIV-infected children. We aimed to evaluate potential underlying cerebral injury by comparing neurometabolite levels between perinatally HIV-infected children and healthy controls....

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Autores principales: Van Dalen, Yvonne W., Blokhuis, Charlotte, Cohen, Sophie, Ter Stege, Jacqueline A., Teunissen, Charlotte E., Kuhle, Jens, Kootstra, Neeltje A., Scherpbier, Henriette J., Kuijpers, Taco W., Reiss, Peter, Majoie, Charles B.L.M., Caan, Matthan W.A., Pajkrt, Dasja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998374/
https://www.ncbi.nlm.nih.gov/pubmed/27015179
http://dx.doi.org/10.1097/MD.0000000000003093
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author Van Dalen, Yvonne W.
Blokhuis, Charlotte
Cohen, Sophie
Ter Stege, Jacqueline A.
Teunissen, Charlotte E.
Kuhle, Jens
Kootstra, Neeltje A.
Scherpbier, Henriette J.
Kuijpers, Taco W.
Reiss, Peter
Majoie, Charles B.L.M.
Caan, Matthan W.A.
Pajkrt, Dasja
author_facet Van Dalen, Yvonne W.
Blokhuis, Charlotte
Cohen, Sophie
Ter Stege, Jacqueline A.
Teunissen, Charlotte E.
Kuhle, Jens
Kootstra, Neeltje A.
Scherpbier, Henriette J.
Kuijpers, Taco W.
Reiss, Peter
Majoie, Charles B.L.M.
Caan, Matthan W.A.
Pajkrt, Dasja
author_sort Van Dalen, Yvonne W.
collection PubMed
description Despite treatment with combination antiretroviral therapy (cART), cognitive impairment is still observed in perinatally HIV-infected children. We aimed to evaluate potential underlying cerebral injury by comparing neurometabolite levels between perinatally HIV-infected children and healthy controls. This cross-sectional study evaluated neurometabolites, as measured by Magnetic Resonance Spectroscopy (MRS), in perinatally HIV-infected children stable on cART (n = 26) and healthy controls (n = 36). Participants were included from a cohort of perinatally HIV-infected children and healthy controls, matched group-wise for age, gender, ethnicity, and socio-economic status. N-acetylaspartate (NAA), glutamate (Glu), myo-inositol (mI), and choline (Cho) levels were studied as ratios over creatine (Cre). Group differences and associations with HIV-related parameters, cognitive functioning, and neuronal damage markers (neurofilament and total Tau proteins) were determined using age-adjusted linear regression analyses. HIV-infected children had increased Cho:Cre in white matter (HIV-infected = 0.29 ± 0.03; controls = 0.27 ± 0.03; P value = 0.045). Lower nadir CD4+ T-cell Z-scores were associated with reduced neuronal integrity markers NAA:Cre and Glu:Cre. A Centers for Disease Control and Prevention (CDC) stage C diagnosis was associated with higher glial markers Cho:Cre and mI:Cre. Poorer cognitive performance was mainly associated with higher Cho:Cre in HIV-infected children, and with lower NAA:Cre and Glu:Cre in healthy controls. There were no associations between neurometabolites and neuronal damage markers in blood or CSF. Compared to controls, perinatally HIV-infected children had increased Cho:Cre in white matter, suggestive of ongoing glial proliferation. Levels of several neurometabolites were associated with cognitive performance, suggesting that MRS may be a useful method to assess cerebral changes potentially linked to cognitive outcomes.
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spelling pubmed-49983742016-09-02 Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children Van Dalen, Yvonne W. Blokhuis, Charlotte Cohen, Sophie Ter Stege, Jacqueline A. Teunissen, Charlotte E. Kuhle, Jens Kootstra, Neeltje A. Scherpbier, Henriette J. Kuijpers, Taco W. Reiss, Peter Majoie, Charles B.L.M. Caan, Matthan W.A. Pajkrt, Dasja Medicine (Baltimore) 4850 Despite treatment with combination antiretroviral therapy (cART), cognitive impairment is still observed in perinatally HIV-infected children. We aimed to evaluate potential underlying cerebral injury by comparing neurometabolite levels between perinatally HIV-infected children and healthy controls. This cross-sectional study evaluated neurometabolites, as measured by Magnetic Resonance Spectroscopy (MRS), in perinatally HIV-infected children stable on cART (n = 26) and healthy controls (n = 36). Participants were included from a cohort of perinatally HIV-infected children and healthy controls, matched group-wise for age, gender, ethnicity, and socio-economic status. N-acetylaspartate (NAA), glutamate (Glu), myo-inositol (mI), and choline (Cho) levels were studied as ratios over creatine (Cre). Group differences and associations with HIV-related parameters, cognitive functioning, and neuronal damage markers (neurofilament and total Tau proteins) were determined using age-adjusted linear regression analyses. HIV-infected children had increased Cho:Cre in white matter (HIV-infected = 0.29 ± 0.03; controls = 0.27 ± 0.03; P value = 0.045). Lower nadir CD4+ T-cell Z-scores were associated with reduced neuronal integrity markers NAA:Cre and Glu:Cre. A Centers for Disease Control and Prevention (CDC) stage C diagnosis was associated with higher glial markers Cho:Cre and mI:Cre. Poorer cognitive performance was mainly associated with higher Cho:Cre in HIV-infected children, and with lower NAA:Cre and Glu:Cre in healthy controls. There were no associations between neurometabolites and neuronal damage markers in blood or CSF. Compared to controls, perinatally HIV-infected children had increased Cho:Cre in white matter, suggestive of ongoing glial proliferation. Levels of several neurometabolites were associated with cognitive performance, suggesting that MRS may be a useful method to assess cerebral changes potentially linked to cognitive outcomes. Wolters Kluwer Health 2016-03-25 /pmc/articles/PMC4998374/ /pubmed/27015179 http://dx.doi.org/10.1097/MD.0000000000003093 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 4850
Van Dalen, Yvonne W.
Blokhuis, Charlotte
Cohen, Sophie
Ter Stege, Jacqueline A.
Teunissen, Charlotte E.
Kuhle, Jens
Kootstra, Neeltje A.
Scherpbier, Henriette J.
Kuijpers, Taco W.
Reiss, Peter
Majoie, Charles B.L.M.
Caan, Matthan W.A.
Pajkrt, Dasja
Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title_full Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title_fullStr Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title_full_unstemmed Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title_short Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children
title_sort neurometabolite alterations associated with cognitive performance in perinatally hiv-infected children
topic 4850
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998374/
https://www.ncbi.nlm.nih.gov/pubmed/27015179
http://dx.doi.org/10.1097/MD.0000000000003093
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