Cargando…
Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis
Interferon gamma (IFN-γ) has antitumor and antiproliferative effects, and previous studies indicated IFN-γ +874T/A (rs2430561) polymorphism were related to the risk of many types of cancer. However, the association between IFN-γ +874T/A polymorphism and leukemia risk remained controversial. We perfo...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998384/ https://www.ncbi.nlm.nih.gov/pubmed/27015189 http://dx.doi.org/10.1097/MD.0000000000003129 |
_version_ | 1782449930420355072 |
---|---|
author | Wu, Zhitong Sun, Yifan Zhu, Shengbo Tang, Shifu Liu, Chunming Qin, Wenzhou |
author_facet | Wu, Zhitong Sun, Yifan Zhu, Shengbo Tang, Shifu Liu, Chunming Qin, Wenzhou |
author_sort | Wu, Zhitong |
collection | PubMed |
description | Interferon gamma (IFN-γ) has antitumor and antiproliferative effects, and previous studies indicated IFN-γ +874T/A (rs2430561) polymorphism were related to the risk of many types of cancer. However, the association between IFN-γ +874T/A polymorphism and leukemia risk remained controversial. We performed a comprehensive meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement (PRISMA). Electronic database of Embase, Pubmed, and the Cochrane Library were searched for eligible articles published up to December 13, 2015. The association between genetic polymorphisms and leukemia risk was measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs). A total of 8 studies amounting to 420 patients and 767 control subjects were retrieved for this study. Although associations between IFN-γ +874T/A polymorphism and overall leukemia risks were lacking, decreased chronic lymphocytic leukemia (CLL) risk was detected in the allelic model (T vs A, OR=0.660, 95%CI = 0.483–0.902, P = 0.009, I(2) = 0.0% and P = 0.863 for heterogeneity), the codominant model (TT vs AA, OR = 0.472, 95%CI = 0.247–0.902, P = 0.023, I(2) = 0.0% and P = 0.994 for heterogeneity), and dominant model (TT + TA vs AA, OR = 0.457, 95%CI = 0.285–0.734, P = 0.001, I(2) = 40.3% and P = 0.195 for heterogeneity) by using fixed-effect model separately. On the contrary, results indicated T carries have an increased chronic myelogenous leukemia (CML) risk in dominant model (TT + TA vs AA, OR = 1.783, 95%CI = 1.236–2.573, P = 0.002, I(2) = 19.0% and P = 0.295 for heterogeneity). This study suggests IFN-γ +874T/A polymorphism are related to CML and CLL risk. In addition, our work also points out IFN-γ +874T/A polymorphism may play dual contrasting role in leukemia risk. |
format | Online Article Text |
id | pubmed-4998384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49983842016-09-02 Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis Wu, Zhitong Sun, Yifan Zhu, Shengbo Tang, Shifu Liu, Chunming Qin, Wenzhou Medicine (Baltimore) 3500 Interferon gamma (IFN-γ) has antitumor and antiproliferative effects, and previous studies indicated IFN-γ +874T/A (rs2430561) polymorphism were related to the risk of many types of cancer. However, the association between IFN-γ +874T/A polymorphism and leukemia risk remained controversial. We performed a comprehensive meta-analysis based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement (PRISMA). Electronic database of Embase, Pubmed, and the Cochrane Library were searched for eligible articles published up to December 13, 2015. The association between genetic polymorphisms and leukemia risk was measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs). A total of 8 studies amounting to 420 patients and 767 control subjects were retrieved for this study. Although associations between IFN-γ +874T/A polymorphism and overall leukemia risks were lacking, decreased chronic lymphocytic leukemia (CLL) risk was detected in the allelic model (T vs A, OR=0.660, 95%CI = 0.483–0.902, P = 0.009, I(2) = 0.0% and P = 0.863 for heterogeneity), the codominant model (TT vs AA, OR = 0.472, 95%CI = 0.247–0.902, P = 0.023, I(2) = 0.0% and P = 0.994 for heterogeneity), and dominant model (TT + TA vs AA, OR = 0.457, 95%CI = 0.285–0.734, P = 0.001, I(2) = 40.3% and P = 0.195 for heterogeneity) by using fixed-effect model separately. On the contrary, results indicated T carries have an increased chronic myelogenous leukemia (CML) risk in dominant model (TT + TA vs AA, OR = 1.783, 95%CI = 1.236–2.573, P = 0.002, I(2) = 19.0% and P = 0.295 for heterogeneity). This study suggests IFN-γ +874T/A polymorphism are related to CML and CLL risk. In addition, our work also points out IFN-γ +874T/A polymorphism may play dual contrasting role in leukemia risk. Wolters Kluwer Health 2016-03-25 /pmc/articles/PMC4998384/ /pubmed/27015189 http://dx.doi.org/10.1097/MD.0000000000003129 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 3500 Wu, Zhitong Sun, Yifan Zhu, Shengbo Tang, Shifu Liu, Chunming Qin, Wenzhou Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title_full | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title_fullStr | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title_full_unstemmed | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title_short | Association of Interferon Gamma +874T/A Polymorphism and Leukemia Risk: A Meta-Analysis |
title_sort | association of interferon gamma +874t/a polymorphism and leukemia risk: a meta-analysis |
topic | 3500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998384/ https://www.ncbi.nlm.nih.gov/pubmed/27015189 http://dx.doi.org/10.1097/MD.0000000000003129 |
work_keys_str_mv | AT wuzhitong associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis AT sunyifan associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis AT zhushengbo associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis AT tangshifu associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis AT liuchunming associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis AT qinwenzhou associationofinterferongamma874tapolymorphismandleukemiariskametaanalysis |